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作 者:孙兴丽 张艳辉[2] 赵敏敏 谭波[2] 张海禄[2] 邓宗武[2] SUN Xing-Li;ZHANG Yan-Hui;ZHAO Min-Min;TAN Bo;ZHANG Hai-Lu;DENG Zong-Wu(School of Nano Technology and Nano Bionics, University of Science and Technology of China, Hefei 230026, China;Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, Suzhou, Jiangsu 215123, China)
机构地区:[1]中国科学技术大学苏州纳米技术与纳米仿生学院,合肥230026 [2]中国科学院苏州纳米技术与纳米仿生研究所,苏州215123
出 处:《无机化学学报》2019年第5期780-786,共7页Chinese Journal of Inorganic Chemistry
基 金:国家自然科学基金(No.21673281;31371010);中国科学院青年创新促进会(No.2012242);中国科学技术部重点研究项目(No.2017YFA0104300)资助
摘 要:将具有良好生物膜穿透性的异烟肼(INH)和Gd-DO3A偶联,合成了小分子MRI造影剂Gd-DO3A-INH;利用脉冲电转染技术标记间充质干细胞,有效提高了进入细胞的Gd-DO3A-INH浓度,并诱导部分游离态Gd-DO3A-INH在细胞质中自组装成纳米粒子。细胞样品的TEM观察到细胞内形成了Gd-DO3A-INH纳米粒子;细胞传代实验和体外MRI揭示了2种不同状态的Gd-DO3A-INH对细胞水质子弛豫速率的影响机制,以及细胞传代过程中细胞内2种不同状态Gd-DO3A-INH的浓度涨落引起的MRI造影效果的变化机制。Isoniazid (INH) was coupled with Gd-DO3A to yield Gd-DO3A-INH as a small molecule MRI contrast agent with good membrane penetration activity. Pulsed electroporation was used to introduce Gd-DO3A-INH into the cytosol of human mesenchymal stem cells in two different forms: free Gd-DO3A-INH and Gd-DO3A-INH nanoclusters. Cellular TEM demonstrated the formation of intracellular Gd-DO3A-INH nanoclusters. Cell proliferation and cellular MRI demonstrated that the two different forms of Gd-DO3A-INH exerted different effect on the longitudinal (T1) and transverse (T2) relaxations of cellular water protons. Free Gd-DO3A-INH is in favor of acceleration of T1 relaxation, and exhibits fast exocytosis. Gd-DO3A-INH nanocluster is in favor of acceleration of T2 relaxation, and exhibits a promoted cell retention time. As a result, cellular MRI exhibits a fast recovery of T1 relaxation and T1-weighted signal intensity/contrast, and a delayed recovery of T2 relaxation and T2-weighted signal intensity/contrast during cell proliferation.
关 键 词:磁共振成像(MRI) Gd基造影剂 弛豫速率 脉冲电转染标记
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