胰岛素泵联合二肽基肽酶-Ⅳ抑制剂治疗新发2型糖尿病的疗效观察  

Effect observation of insulin pump combined with dipeptidyl peptidase-Ⅳ inhibitor on the treatment of newly diagnosed type 2 diabetes mellitus

作　　者：陈英姿[1] 孟信龙[1] 杜鹏 缪从庆 樊爱娟 刘敬敬 陆德川 CHEN Yingzi;MENG Xinlong;DU Peng;MIU Congqing;FAN Aijuan;LIU Jingjing;LU Dechuan(Department of Endocrinology,Jiangdu People′s Hospital Affiliated to Medical College of Yangzhou University,Yangzhou,Jiangsu,225200)

机构地区：[1]扬州大学医学院附属扬州市江都人民医院内分泌科,江苏扬州225200

出　　处：《实用临床医药杂志》2019年第8期22-24,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨胰岛素泵联合二肽基肽酶-Ⅳ(DPP-Ⅳ)抑制剂治疗新诊断2型糖尿病(T2DM)的效果。方法将51例新诊断T2DM患者随机分为试验组(胰岛素泵联合DPP-Ⅳ抑制剂)与对照组(单用胰岛素泵)。治疗15 d后比较2组临床疗效。结果治疗后,2组血糖相关指标均显著改善(P <0. 05),且试验组血糖控制显著优于对照组(P <0. 05)。试验组胰岛β细胞功能指数、C肽曲线下面积、胰岛素抵抗指数显著优于对照组(P <0. 05)。试验组胰岛素用量、血糖完全达标比例、血糖达标时间、体质量增加值均显著优于对照组(P <0. 01)。试验组低血糖发生率为8. 00%(2/26),对照组为12. 00%(3/25),2组差异无统计学意义(P> 0. 05)。治疗过程中,2组均未发生严重低血糖事件以及肝、肾功能损害。结论胰岛素泵联合DPP-Ⅳ抑制剂治疗新诊断T2DM的效果显著,能有效控制血糖,减轻胰岛素抵抗,减少体质量增加。Objective To investigate the effect of insulin pump combined with dipeptidyl peptidase-Ⅳ(DPP-Ⅳ)inhibitor on the treatment of newly diagnosed type 2 diabetes mellitus(T2DM).Methods Totally 51 newly diagnosed patients with T2DM were randomly divided into experimental group(insulin pump combined with DPP-Ⅳinhibitor)and control group(insulin pump alone).After 15 days of treatment,the clinical effect was compared between two groups.Results After treatment,the blood sugar related indexes in both groups significantly improved(P<0.05),and the blood sugar control of the experimental group was significantly better than that of the control group(P<0.05).The pancreaticβcell function index,area under curve of C-peptide and insulin resistance index in the experimental group were significantly better than those in the control group(P<0.05).The dosage of insulin,the ratio of patients with blood sugar reaching the standard completely,the time of blood sugar reaching the standard and the increase value of body mass in the experimental group were significantly better than those in the control group(P<0.01).The incidence rate of hypoglycemia was 8.00%(2/26)in the experimental group and 12.00%(3/25)in the control group,and there was no significant difference between the two groups(P>0.05).During the treatment,no severe hypoglycemic events and liver and kidney function damage occurred in both groups.Conclusion Insulin pump combined with DPP-Ⅳinhibitor is effective in the treatment of newly diagnosed T2DM,which can effectively control blood sugar,reduce insulin resistance and weight gain.

关 键 词：2型糖尿病 胰岛素泵 二肽基肽酶-Ⅳ 胰岛β细胞功能指数 胰岛素抵抗指数 C肽 

分 类 号：R587.1[医药卫生—内分泌]