肌少症在慢性放射性肠炎合并肠梗阻病人中的发生率及围手术期影响  

Incidence and complications associated with sarcopenia in chronic radiation enteritis patients complicated with intestinal obstruction

作　　者：邵国益[1] 赵振国[1] SHAO Guo-yi;ZHAO Zhen-guo(Department of General Surgefy, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin 214400, Jiangsu, China)

机构地区：[1]东南大学医学院附属江阴医院普通外科,江苏江阴214400

出　　处：《肠外与肠内营养》2019年第2期91-94,共4页Parenteral & Enteral Nutrition

基　　金：无锡市卫计委青年科研项目基金(NO.Q201720);黎介寿肠道屏障专项基金(NO.LJS-201708)

摘　　要：目的:研究肌少症在慢性放射性肠炎(CRE)合并肠梗阻病人中发生率及对手术治疗的近期影响。方法:回顾性分析84例CRE合并肠梗阻并接受病变部位外科手术病人的临床资料。结果:84例病人中,肌少症35例(41.67%)。肌少症组病人放疗时程、营养风险筛查2002(NRS 2002)评分和超敏C反应蛋白(hs-CRP)与非肌少症组比较有显著性差异(P <0.05)。肌少症组病人感染性并发症发生率较非肌少症组显著增加,术后住院时间显著延长(P <0.05)。肌少症与放疗时程、NRS 2002评分差异、hs-CRP呈负相关(r=-0.786、-0.698、-0.639,P <0.05)。结论:肌少症在CRE合并肠梗阻病人中发生率较高,可增加感染性并发症发生率、延长住院时间,与病人放疗时程、营养风险及炎症状态有一定相关性。Objective: To study the incidence and surgical outcomes associated with sarcopenia in chronic radiation enteritis(CRE) patients complicated with intestinal obstruction. Methods: The clinical data of 84 patients with CRE combined with intestinal obstruction who underwent surgical resection were retrospectively analyzed.Results: The incidence of sarcopenia was 41.67%(35 of 84). Significant differences were observed in the radiotherapy duration, nutritional risk screening 2002(NRS 2002) score and the hypersensitive C-reactive protein(hs-CRP) between the two groups(P < 0.05). Infectious complications and postoperative hospitalization time in sarcopenia group were significantly deteriorated than non-sarcopenia group. Sarcopenia was negatively correlated with radiotherapy duration,NRS 2002 score, and hs-CRP(r =-0.786,-0.698,-0.639, P < 0.05). Conclusion: Sarcopenia has a high incidence in CRE patients combined with intestinal obstruction. Sarcopenis can increase the incidence of infectious complications and prolong the time of hospitalization. Sarcopenis is correlated with radiotherapy duration, nutritional risk and inflammatory status.

关 键 词：肌少症 慢性放射性肠炎 营养风险 并发症 

分 类 号：R459.3[医药卫生—治疗学]