脂必泰胶囊对高脂血症大鼠血脂和血糖及脂肪细胞因子网膜素的影响  

Effects of Zhibitai capsule on blood lipids,blood glucose and the adipocytokine omentin in hyperlipidemic rats

作　　者：王电烨 杨丽敏 胡志耕[1] Wang Dianye;Yang Limin;Hu Zhigeng(Department of Cardiovascular Medicine,the Affiliated Hospital of Shanxi College of Traditional Chinese Medicine,Taiyuan,Shanxi 030024,China)

机构地区：[1]山西中医学院附属医院心病科,太原030024

出　　处：《中国基层医药》2019年第6期712-715,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的研究脂必泰胶囊对高脂血症大鼠血脂、血糖及网膜素的作用.方法将30只SPF级雄性大鼠采用随机数字表方法平均分成对照组、模型组、脂必泰组,对照组饲以普通饲料,其余大鼠饲以高脂饲料,造模成功后,脂必泰组分别以8 mg/kg脂必泰胶囊粉每日2次灌胃处理,对照组、模型组,分别予以等量的0.9%氯化钠注射液,4周后测定各组大鼠血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、血糖及网膜素-1.结果脂必泰组与模型组比较,大鼠血清TC[(3.97±0.62)mmol/L比(6.33±1.10)mmol/L,t=5.910,P<0.01]、TG[(1.51±0.47)mmol/L比(2.18±0.64)mmol/L,t=2.472,P<0.05]、LDL-C[(0.30±0.04)mmol/L比(0.48±0.16)mmol/L,t=3.451,P<0.01)]水平显著降低,HDL-C水平显著升高[(1.35±0.28)mmol/L比(1.06±0.31)mmol/L,t=2.195,P<0.05],血糖显著下降[(5.04±0.82)mmol/L比(6.43±1.10)mmol/L,t=3.204,P<0.01],网膜素-1浓度明显升高[(68.59±24.82)ng/L比(46.86±20.12)ng/L,t=2.151,P<0.05].结论脂必泰胶囊能有效降低高脂血症大鼠血清中TC、TG、LDL-C,提高大鼠血清中高密度脂蛋白HDL-C,有效降低血糖,并能升高网膜素含量.Objective To study the effect of Zhibitai capsule on blood lipids,blood glucose and omentin in hyperlipidemic rats. Methods Thirty SPF male rats were randomly divided into control group,model group and Zhibitai group. The control group was fed with common diet,while the rest rats were fed with high - fat diet. After the model was successfully established,the Zhibitai group was orally administered 8mg/ kg Zhibitai capsule powder twice daily,the rats in the control group and the model group were given the same amount of normal saline respectively. After 4 weeks,the serum levels of total cholesterol (TC),triglyceride (TG),high density lipoprotein (HDL - C),low density lipoprotein (LDL - C),blood glucose and omentin were evaluated. Results Compared with the model group, the serum levels of TC[(3. 97 ± 0. 62) mmol/ L vs.(6. 33 ± 1. 10) mmol/ L,t = 5. 910,P < 0. 01],TG[(1. 51 ± 0. 47)mmol/ L vs.(2. 18 ± 0. 64)mmol/ L,t = 2. 472,P < 0. 05]and LDL - C[(0. 30 ± 0. 04)mmol/ L vs.(0. 48 ± 0. 16)mmol/ L,t = 3. 451,P < 0. 01)] of the Zhibitai group were significantly decreased,the HDL - C level was significantly increased[(1. 35 ± 0. 28) mmol/ L vs.(1. 06 ± 0. 31) mmol/ L,t = 2. 195,P < 0. 05],blood glucose decreased significantly[(5. 04 ±0. 82)mmol/ L vs.(6. 43 ± 1. 10)mmol/ L,t = 3. 204,P < 0. 01],and the concentration of omentin was significantly increased[(68. 59 ± 24. 82) ng/ L vs.(46. 86 ± 20. 12) ng/ L,t = 2. 151,P < 0. 05]. Conclusion Zhibitai capsule can effectively reduce the serum levels of TC,TG and LDL - C of hyperlipidemic rats and increase the content of HDL - C,effectively reduce blood sugar,and can increase the content of omentin.

关 键 词：高脂血症 脂必泰 胆固醇 甘油三酯类 脂蛋白类 血糖 脂肪因子类 大鼠 

分 类 号：R965[医药卫生—药理学]