中国成年双生子人群的糖尿病遗传度研究  

Analysis on the heritability of diabetes, based on data from the Chinese adult twins

作　　者：甘凤夏 高文静[1] 吕筠[1] 余灿清[1] 王胜锋[1] 逄增昌[2] 丛黎明[3] 董忠[4] 吴凡[5] 汪华[6] 吴先萍[7] 江国虹[8] 王晓节[9] 王滨有[10] 畅征 Ralf Kuja-Halkola 曹卫华[1] 李立明[1] Gan Fengxia;Gao Wenjing;Lyu Jun;Yu Canqing;Wang Shengfeng;Pang Zengchang;Cong Liming;Dong Zhong;Wu Fan;Wang Hua;Wu Xianping;Jiang Guohong;Wang Xiaojie;Wang Binyou;Chang Zheng;Kuja-Halkola Ralf;Cao Weihua;Li Liming(Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;Harbin Medical University, Harbin 150001, China;Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden;Qingdao Center for Disease Control and Prevention, Qingdao 266033, China;Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, China;Beijing Center for Disease Control and Prevention, Beijing 100013, China;Shanghai Center for Disease Control and Prevention, Shanghai 200336, China;Jiangsu Center for Disease Control and Prevention, Nanjing 210008, China;Sichuan Center for Disease Control and Prevention, Chengdu 610041, China;Tianjin Center for Disease Control and Prevention, Tianjin 300011, China;Qinghai Center for Disease Control and Prevention, Xining 810007, China)

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,100191 [10]哈尔滨医科大学,150001 [11]瑞典卡罗林斯卡医学院流行病学与生物统计学系,斯德哥尔摩17177 [2]青岛市疾病预防控制中心,266033 [3]浙江省疾病预防控制中心,杭州310051 [4]北京市疾病预防控制中心,100013 [5]上海市疾病预防控制中心,200336 [6]江苏省疾病预防控制中心,南京210008 [7]四川省疾病预防控制中心,成都610041 [8]天津市疾病预防控制中心,300011 [9]青海省疾病预防控制中心,西宁810007

出　　处：《中华流行病学杂志》2019年第4期389-393,共5页Chinese Journal of Epidemiology

基　　金：公益性行业科研专项(201502006,201002007);国家自然科学基金(81711530051).

摘　　要：目的分析中国成年双生子人群的糖尿病遗传度。方法利用中国双生子登记系统9省市的10253对同性别双生子进行面访式问卷调查的相关信息,通过结构方程模型计算糖尿病的遗传度。结果调整年龄和性别后,糖尿病的遗传度为0.41(0.15~0.75);进一步亚组分析显示,<45和≥45岁组的遗传度分别为0.83(0.72~0.91)和0.34(0.04~0.73),男、女性的遗传度分别为0.37(0.05~0.78)和0.88(0.79~0.94)。结论糖尿病受遗传和环境因素的共同影响,女性双生子糖尿病的遗传效应高于男性,年龄越大,遗传效应越小。Objective To analyze the heritability of diabetes among the Chinese twin adults. Methods A total of 10 253 same-sex twin pairs aged 25 years and older, were selected from the Chinese National Twin Registry (CNTR) program. Heritability of diabetes was calculated by using the structural equation model. Results After adjusted for age and gender, the overall heritability rates of diabetes were 0.41 (0.15-0.75), 0.83 (0.72-0.91) and 0.34 (0.04-0.73) in the <45 and ≥45 years twin pairs, respectively. After adjusted for age, rates of heritability appeared as 0.37 (0.05-0.78) and 0.88 (0.79-0.94) in men and women, respectively. Conclusions Diabetes is affected by both genetic and environmental factors. The genetic effect of diabetes seemed stronger on female than that on male twins but was dying down along with ageing.

关 键 词：糖尿病 双生子研究 遗传度 

分 类 号：R587.1[医药卫生—内分泌]