国际癌症研究机构与美国环保署有关草甘膦致癌性证据的回顾  

Review of evidences on carcinogenicity of glyphosate used by International Agency for Research on Cancer and US Environmental Protection Agency

作　　者：倪志晶 孙玮奇 周志俊[1] NI Zhi-jing;SUN Wei-qi;ZHOU Zhi-jun(School of Public Health/Key Laboratory of Public Health and Safety of Ministry of Education, Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学公共卫生学院/教育部公共卫生安全重点实验室,上海200032

出　　处：《环境与职业医学》2019年第3期287-293,F0004,共8页Journal of Environmental and Occupational Medicine

基　　金：上海市三年行动计划项目(GW4-27.3;15GWZK0202)

摘　　要：国际癌症研究机构(International Agency for Research on Cancer,IARC)于2015年3月发布评估报告将草甘膦列入"2A"类致癌物,自此引发了关于草甘膦究竟是否具有致癌性的争议。之后,美国环保署(Environmental Protection Agency,EPA)再次对草甘膦进行了致癌性评估,认为草甘膦"不太可能致癌"。基于草甘膦的安全性一直备受关注与热议,文章总结了IARC与EPA两机构评估报告中所参照的研究数据,从流行病学研究、动物实验研究和其他致癌性证据三个方面入手,重点描述了其中具有阳性结论的数据,旨在客观反映两机构作出不同评估结论的原因主要在于他们所引用的研究数据存在差异。The International Agency for Research on Cancer(IARC) issued an assessment report in March 2015 that listed glyphosate as a "2 A" carcinogen, and triggered a controversy over whether glyphosate was carcinogenic. After that US Environmental Protection Agency(EPA) released a report on carcinogenic evaluation of glyphosate with a conclusion that glyphosate was "unlike to cause cancer". In view of the constant attention to glyphosate safety, this article summarized the research data used by IARC and EPA in their evaluation reports, including human epidemiological studies, animal experiments, and other carcinogenic evidence, focusing on the data with positive conclusions. It aimed to objectively reflect the fact that the different conclusions made by IARC and USEPA were resulted from the different data they used in their evaluations.

关 键 词：草甘膦 IARC EPA 致癌性 

分 类 号：R114[医药卫生—卫生毒理学]