激素序贯疗法与去氧孕烯炔雌醇片口服治疗青春期功能失调性子宫出血的疗效及安全性对比  

Comparison of Efficacy and Safety of Hormone Sequential Therapy and Oral Pregnancy Estradiol Tablets for Adolescent Dysfunctional Uterine Bleeding

作　　者：刘茂永 黄露[1] 龚乾涛 王丹[1] 简远丽 罗丽娜[1] Liu Maoyong;Huang Lu;Gong Gantao;Wang Dan;Jian Yuanli;Luo Lina(Department of Obstetrics and Gynecology,The First People's Hospital of Zunyi,Guizhou Province,Zunyi Guizhou 563000)

机构地区：[1]贵州省遵义市第一人民医院妇产科,贵州遵义563000

出　　处：《辽宁医学杂志》2019年第1期55-58,共4页Medical Journal of Liaoning

摘　　要：目的探讨激素序贯疗法与去氧孕烯炔雌醇片在青春期功能失调性子宫出血治疗中的应用价值。方法选取2015年3月～2017年9月收治的青春期功能失调性子宫出血患者188例为研究对象,以随机数字表法分为A组94例,B组94例,A组给予去氧孕烯炔雌醇片治疗,B组给予激素序贯疗法治疗,观察两组治疗效果,止血情况,治疗前、治疗3个月后性激素水平、子宫内膜厚度变化及不良反应发生情况。结果 A组治疗总有效率为95.74%,同B组80.85%对比,差异有统计学意义(P<0.05),A组出血控制时间、出血停止时间及血红蛋白复常时间同B组对比,明显较短,差异有统计学意义(P<0.05),治疗前两组宫内膜厚度、性激素水平差异无统计学意义(P>0.05),A组治疗3个月后子宫内膜厚度与同期B组对比,明显较小,血清促卵泡激素(FSH)、雌二醇(E2)水平与同期B组对比,明显较低,差异有统计学意义(P<0.05);A组用药期间不良反应发生率为8.51%,同B组25.53%对比,差异有统计学意义(P<0.05)。结论相比于激素序贯疗法,去氧孕烯炔雌醇片治疗青春期功能失调性子宫出血,止血更为迅速,对性激素及子宫内膜改善作用更明显,疗效确切,安全性高,值得推广。Objective To investigate the value of hormone sequential therapy and desogestrel therapy in the treatment of dysfunctional uterine bleeding in adolescents. Methods Select 188 patients with adolescent dysfunctional uterine bleeding from March 2015 to September 2017 as study subjects. The random number table method was used to classify 94 cases in group A and 94 cases in group B. Group A was treated with desogestrel ethinyl estradiol tablets,and Group B was treated with hormone sequential therapy. Observed the effects of treatment,hemostasis,pre-treatment,sex hormone levels,endometrial thickness changes,and occurrence of adverse reactions. Results The total effective rate in group A was 95. 74%,which was significantly higher than that in group B ( 80. 85%). The difference was statistically significant ( P < 0. 05). The bleeding control time,bleeding stop time,and hemoglobin recovery time in group A were significantly shorter than those in group B,and the difference was statistically significant ( P < 0. 05). There were no significant difference in endometrial thickness and sex hormone levels between the two groups before treatment ( P > 0. 05). Endometrial thickness was significantly smaller in group A after 3 months of treatment compared with group B in the same period. Serum follicle-stimulating hormone ( FSH),the level of estradiol ( E2) were significantly lower than that of group B during the same period,and the difference was statistically significant ( P < 0. 05). The incidence of adverse reactions during group A medication was 8. 51%,compared with 25. 53% in group B,the difference was statistically significant ( P < 0. 05). Conclusion Compared to sequential hormone therapy,desogestrel therapy is effective in the treatment of dysfunctional uterine bleeding during puberty,hemostasis is more rapid,and the effects of sex hormones and endometrial improvement are more pronounced,the efficacy is definite,and the safety is high. It is worth promoting.

关 键 词：功能失调性子宫出血 青春期 去氧孕烯炔雌醇片 激素序贯疗法 

分 类 号：R711.52[医药卫生—妇产科学]