小剂量德巴金防治小儿复杂性热性惊厥的安全性和有效性分析  

Safety and Efficacy of Low-Dose Sodium Valproate in Prevention and Treatment of Infantile Complicated Febrile Seizures

作　　者：李贞[1] Li Zhen(Department of Pediatrics,Anyang Maternal and Child Health Hospital Anyang,Henan 455000)

机构地区：[1]河南省安阳市妇幼保健院儿科,河南安阳455000

出　　处：《辽宁医学杂志》2019年第1期74-76,共3页Medical Journal of Liaoning

摘　　要：目的探讨小剂量德巴金防治小儿复杂性热性惊厥的安全性和有效性分析。方法选取2016年2月至2017年12月我院收治的小儿复杂性热性惊厥患儿58例作为研究对象,按照随机数字法分为观察组(32例)与对照组(26例),对照组采取常规治疗基础中给予标准剂量的德巴金丙戊酸钠口服溶液(20～30mg·kg^(-1)·次^(-1)、2次·d^(-1)),观察组采取常规治疗基础中给予小剂量德巴金丙戊酸钠口服溶液(10～15mg·kg^(-1)·d^(-1)、2次·d^(-1))。观察两组用药12h、24h后惊厥、意识及体温情况,比较两组不良反应,经随访1年比较两组复发与继发癫痫情况。结果两组患儿给药12h、24h后惊厥控制、意识恢复及体温恢复组间差异无统计学差异(P>0.05);两组患儿不良反应发生率分别为15.63%、53.84%,且观察组不良反应总发生率明显低于对照组(P<0.05);经12个月随访后,观察组复发1例,对照组复发3例,组间无统计学差异(P>0.05),且两组随访结束后继发癫痫均1例,组间无统计学差异(P>0.05)。结论临床中针对小儿复杂性热性惊厥疾病治疗给予小剂量德巴金丙戊酸钠口服溶液治疗,可改善患儿体温,患儿可早期恢复意识,小剂量与正常剂量可达到相同的治疗效果,且不良反应显著降低,复发率与继发癫痫发生率无上升确实,可见小剂量用药的安全性。Objective To investigate the safety and efficacy of low-dose sodium valproate in prevention and treatment of infantile complicated febrile seizures. Methods A total of 58 children with complicated febrile seizures admitted to our hospital from February 2016 to December 2017 were enrolled and divided into two groups according to random number method. The control group ( n = 26) received the routine treatment combined with the standard dose of sodium valproate ( 20 ~ 40mg·kg -·1 d - 1 ),while the observation group ( n = 32) received the routine treatment combined with the low dose of sodium valproate ( 10 ~ 20mg·kg -·1 d - 1 ). The recovery of convulsions,consciousness and body temperature were observed in both groups at the post-treatment 12h and 24h. The adverse reactions,the recurrence and secondary epilepsy were also compared between the two groups during the1-year follow-up. Results The recovery of convulsions,consciousness and body temperature at the post-treatment 12h and 24h had no difference in both groups ( P > 0. 05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group ( 15. 63% vs 53. 84%,P < 0. 05). During the follow-up period,the recurrence occurred in 1 case in the observation group and 3 cases in control group,with no statistic difference ( P > 0. 05). A total of 1 case of secondary epilepsy occurred,with no difference between groups ( P > 0. 05). Conclusion The application of low-dose sodium valproate can effectively and safely promote the recovery of convulsions,consciousness and body temperature for infantile complicated febrile seizures,and the adverse reaction is less occurred compared with children receiving standard dose,meanwhile,no increase is found in recurrence and secondary epilepsy rates.

关 键 词：小儿复发性热性惊厥 德巴金丙戊酸钠口服溶液 小剂量 安全性 有效性 

分 类 号：R720.597[医药卫生—急诊医学]