盐酸坦洛新和COX-2抑制剂治疗前列腺增生症患者下尿路症状的临床研究  

Controlled clinical study of a COX-2 inhibitor plus tamsulosin hydrochloride for the treatment of lower urinary tract symptoms(LUTS) secondary to benign prostatic hyperplasia

作　　者：董晓飞[1] 白强[2] Dong Xaofei;Bai Qiang(Department of Urology,People's hospital of Anji county,Zhejiang 313300,China;Department of Urology,Xinhua Hospital,Shanghai Jiaotong University School of Medicine)

机构地区：[1]浙江省安吉县人民医院泌尿外科,浙江安吉313300 [2]上海交通大学医学院附属新华医院泌尿外科

出　　处：《中国男科学杂志》2019年第1期57-60,共4页Chinese Journal of Andrology

摘　　要：目的观察盐酸坦洛新和COX-2抑制剂短期治疗前列腺增生(BPH)伴下尿路症状(LUTS)的疗效和安全性;并与盐酸坦洛新单独使用相比较。方法110例良性前列腺增生伴LUST的患者随机分成治疗组(塞来昔布+盐酸坦洛新)55例和对照组(单一使用盐酸坦洛新)55例。两组前列腺症状评分(IPSS)、膀胱过度活动综合症(OABSS)评分、最大尿流率(Qmax)、残余尿(RUV)、血清前列腺特异性抗原(PSA)等指标被记录,并进行统计学分析。结果治疗后治疗组和对照组的总IPSS,储尿期IPSS,排尿期IPSS.Qmax.OABSS和RUV都得到了明显改善,与治疗前相比差异有统计学意义(P<0.05);治疗组RUV从(63.3±51.5)mL降低为(25.0±26.2)mL,差异具有统计学意义(P<0.05)。此外,总IPSS,储尿期IPSS,排尿期IPSS和OABSS评分改善程度也都优于对照组,差异具有统计学意义(P<0.05)。另外,在治疗过程中也未发生明显药物的不良反应。结论塞来昔布+盐酸坦洛新联合用药能安全有效地改善治疗BPH引起的的LUST症状,并且优于单一使用盐酸坦洛新的疗效。Objective To explore short-term efficacy of a COX-2 inhibitor plus tamsulosin hydrochloride for the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia,and compare this combination therapy with tamsulosin hydrochloride alone. Methods A total of 110 patients with BPH-induced LUTS were divided into two group. The ptients in the treatment group were administrated with tamsulosin hydrochloride 0.2mg plus celecoxib 200mg and the patients in the control group with tamsulosin hydrochloride 0.2mg treatment The International Prostatic Symptom Score (IPSS), maximal urinary flow rates (Qmax, Overactive Bladder Symptom Score(OABSS) and residual urine volume(RUV) of all patients, as efficacy parameters, were recorded at baseline and again at 8 weeks. Results After a 8-week treatment, compared with baseline, the total IPSS, IPSS(storage), IPSS(voiding),OABSS and RUV of patients in two groups were all improved in comparison with tamsulosin hydrochloride alone group (P<0.05). Conclusion Our results suggest that combination therapy of a COX-2 inhibitor plus tamsulosin hydrochloride was superior to tamsulosin hydrochloride alone in the treatment of LUST secondary to benign prostatic hyperplasia.

关 键 词：前列腺增生/药物疗法 环氧化酶2抑制剂 药物治疗 

分 类 号：R697.32[医药卫生—泌尿科学]