Energy Cost and Mean Dwell Times for the Activity of Promoter with Complex Structure  

作　　者：LI Qingqing DIN Anwarud ZHOU Tianshou 

机构地区：[1]Guangdong Province Key Laboratory of Computational Science, School of Mathematics, Sun Yat-Sen University

出　　处：《Journal of Systems Science & Complexity》2019年第2期510-525,共16页系统科学与复杂性学报（英文版）

基　　金：supported by Science and Technology Department under Grant No.2014CB964703;the Natural Science Foundation under Grant Nos.91530320 and 11761025

摘　　要：Regulatory molecules present on the core promoter of a gene interact often in a dynamic,highly combinatorial and possibly energy-dependent manner, leading to complex promoter structure and even complex global dynamics. The authors analyze dynamics of an arbitrarily complex promoter from the view of thermodynamics combined with statistic physics. First, the authors formulize transcription factors-mediated promoter kinetics in terms of energy. Then, the authors analyze energetic cost in several representative cases of promoter structure, deriving useful analytical results. Third, the authors derive analytical expressions for mean dwell times of the promoter activity states, experimentally measurable quantities related to the energy cost of promoter dynamics. The overall framework lays a theoretical foundation for analysis of complex promoter kinetics and gene expression dynamics.Regulatory molecules present on the core promoter of a gene interact often in a dynamic,highly combinatorial and possibly energy-dependent manner, leading to complex promoter structure and even complex global dynamics. The authors analyze dynamics of an arbitrarily complex promoter from the view of thermodynamics combined with statistic physics. First, the authors formulize transcription factors-mediated promoter kinetics in terms of energy. Then, the authors analyze energetic cost in several representative cases of promoter structure, deriving useful analytical results. Third, the authors derive analytical expressions for mean dwell times of the promoter activity states, experimentally measurable quantities related to the energy cost of promoter dynamics. The overall framework lays a theoretical foundation for analysis of complex promoter kinetics and gene expression dynamics.

关 键 词：ENERGETIC cost MASTER equation mean DWELL time PROMOTER kinetics regulation 

分 类 号：O1[理学—数学]