地诺前列酮栓与米索前列醇对子痫前期患者引产效果的比较  

Comparison of effect of Dinoprostone Suppository and Misoprostol on induced labor in patients with preeclampsia

作　　者：梁正仪[1] LIANG Zheng-yi(Department of Obstetrics,Maternal and Child Health Care Hospital of Jiangxi Province,Nanchang 330046,China)

机构地区：[1]江西省妇幼保健院产科,江西南昌330046

出　　处：《中国当代医药》2019年第11期112-114,118,共4页China Modern Medicine

摘　　要：目的探讨地诺前列酮栓与米索前列醇两种促宫颈成熟药物在子痫前期患者终止妊娠过程中的有效性和安全性。方法选取我院2015年1月～2017年12月收治的60例终止妊娠的宫颈不成熟子痫前期患者作为研究对象,根据促宫颈成熟药物给药方案分为观察组与对照组,各30例。观察组采用米索前列醇,对照组采用地诺前列酮栓。比较两组的促宫颈成熟效果、引产效果、阴道分娩情况、母婴不良反应发生率等指标。结果观察组的促宫颈成熟有效率为88.67%,与对照组的83.33%比较,差异无统计学意义(P>0.05)。观察组的平均阴道出血量为(279.76±69.14)ml,与对照组的(267.95±71.02)ml比较,差异无统计学意义(P>0.05)。观察组的母婴不良反应发生率为53.3%,与对照组的43.3%比较,差异无统计学意义(P>0.05)。观察组的阴道分娩率为83.33%,明显高于对照组的63.33%,差异有统计学意义(P<0.05)。结论地诺前列酮栓与米索前列醇两种药物均能安全有效地促宫颈成熟,使子痫前期患者阴道分娩率大幅度提高,米索前列醇促宫颈成熟后阴道分娩率更高,地诺前列酮栓的安全性更好,两种药物均值得临床推广。Objective To investigate the efficacy and safety of Dinoprostone Suppository and Misoprostol in the termination of pregnancy in patients with preeclampsia.Methods A total of 60 preeclampsia patients with immature cervix who were terminated from January 2015 to December 2017 in our hospital were selected as subjects.According to the medication regimen for promoting cervical ripening,all patients were divided into the observation group and the control group,30 cases in each group.Misoprostol was used in the observation group,and Dinoprostone Suppository was used in the control group.The effects of cervical ripening,induced labor,vaginal delivery and the incidence of maternal and infant adverse reactions were compared between the two groups.Results The effective rate of cervical ripening in the observation group was 88.67%,and there was no significant difference compared with 83.33% in the control group(P>0.05).The mean vaginal bleeding in the observation group was(279.76±69.14)ml,and there was no significant difference compared with(267.95±71.02)ml in the control group(P>0.05).The rate of maternal and infant adverse reactions in the observation group was 53.3%,and there was no significant difference compared with 43.3%in the control group(P>0.05).The rate of vaginal delivery in the observation group was 83.33%,which was significantly higher than that of the control group(63.33%),and the data was statistically significant(P<0.05).Conclusion Both of Dinoprostone Suppository and Misoprostol can promote cervical maturation safely and effectively,which greatly increases the rate of vaginal delivery in patients with preeclampsia,with higher rate of vaginal delivery after misoprostol promoting cervical maturation,and the safety of Dinoprostone Suppository is better.Both drugs are worthy of clinical promotion.

关 键 词：子痫前期 终止妊娠 地诺前列酮栓 米索前列醇 临床应用 

分 类 号：R714.46[医药卫生—妇产科学]