聚丁二酸丁二醇酯载药体系释药通道调控及其对药物释放行为的影响  

Preparation of Poly (butylene succinate)-Based Drug Delivery System and Drug Release Behavior

作　　者：潘瑞 陈蓉[1] 吴宏[1] 郭少云[1] Rui Pan;Rong Chen;Hong Wu;Shaoyun Guo(State Key Laboratory of Polymer Materials Engineering ,Polymer Research Institute,Sichuan University ,Chengdu 610065 ,China)

机构地区：[1]高分子材料工程国家重点实验室(四川大学)四川大学高分子研究所,四川成都610065

出　　处：《高分子材料科学与工程》2019年第4期73-78,86,共7页Polymer Materials Science & Engineering

基　　金：教育部"长江学者和创新团队发展计划资助"项目(IRT-15R48)

摘　　要：以生物降解材料聚丁二酸丁二醇酯(PBS)为基体,水溶性药物酒石酸美托诺尔(MPT)为模型药物,熔融共混制备了不同载药量的药物释放体系,并设计不同热处理方式(淬冷和90℃等温1 h)调控基体的结晶行为,探讨了基体结晶行为对载药体系释药行为的影响。通过偏光显微镜、差示扫描量热法和扫描电子显微镜等分析了载药体系在不同热处理条件下基体的结晶形态变化,研究了不同热处理方式对载药体系释药行为的影响机理。结果表明,在释药中期,90℃处理载药样品的释药速率明显快于淬冷样品;在释药后期,2种体系释药行为差别不大。Biodegradable poly (butylene succinate)(PBS) based drug delivery systems were prepared through melt-blending, with different loading contents of a model drug, metoprolol tartrate (MPT). Different heat treatment methods were employed to adjust the crystallization behavior of PBS, and its effect on the drug release behavior was systematically discussed. The crystalline morphology and melting behavior of the matrix were analyzed through polarized optical microscope and differential scanning calorimetry (DSC), and the effect of heat treatment on the drug release mechanism was explained. Based on the in-vitro release results, the drug release rate of the heat treated samples is significantly faster than that of the quenched samples in the first 300 h of immersion. After that, the two samples exhibit similar drug release behaviors.

关 键 词：聚丁二酸丁二醇酯 熔融共混 热处理 释药通道 药物释放行为 

分 类 号：TQ323.4[化学工程—合成树脂塑料工业]