Collective Synthesis of Schilancidilactones A, B and Schilancitrilactones A, B, C, 20‐epi‐Schilancitrilactone A  

作　　者：Hengtao Wang Liang Wang Yihang Li Xiunan Zhang Pingping Tang 

机构地区：[1]State Key Laboratory and Institute of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China [2]Collaborative Innovation Center of Chemical Science and Engineering,Tianjin 300071,China

出　　处：《Chinese Journal of Chemistry》2019年第3期255-268,共14页中国化学（英文版）

摘　　要：Summary of main observation and conclusion Schisandraceae triterpenoids are novel natural products that contain highly fused ring systems bearing multiple chiral centers surrounding. Some of them exhibit promising bioactivities, such as antitumor, anti‐HIV, etc. In this article, we describe our efforts to the collective total synthesis of schilancidilactones A, B, schilancitrilactones A, B, C, and 20‐epi‐schilancitrilactone A from common precursors. An intramolecular radical cyclization, late‐stage halogenation and AIBN‐mediated or Ni‐catalyzed intermolecular radical cross coupling reaction were employed as the key steps.

关 键 词：EPI multiple STAGE RING AIBN HIV OUR 

分 类 号：TQ433[化学工程]