青少年吸烟史、糖尿病发病年龄与糖尿病视网膜病变的相关性分析  

Association of adolescent smoking history and onset age of diabetes with diabetic retinopathy

作　　者：郝兆虎[1] 邵海琳[1] 黄霄 方涛[1] 田凤石[1] Hao Zhaohu;Shao Hailin;Huang Xiao;Fang Tao;Tian Fengshi(Department of Metabolic Disease Management Center,Tianjin 4th Central Hospital,The Fourth Clinical College of Tianjin Medical University,Tianjin 300140,China;NHC Key Laboratory of Hormones and Development(Tianjin Medical University),Tianjin Key Laboratory of Metabolic Diseases,Tianjin Medical University Metabolic Diseases Hospital & Tianjin Institute of Endocrinology,Tianjin 300070,China)

机构地区：[1]天津市第四中心医院代谢性疾病管理中心、天津医科大学第四临床学院,300140 [2]国家卫生健康委员会激素与发育重点实验室(天津医科大学)、天津市代谢性疾病重点实验室、天津医科大学代谢病医院内分泌研究所,300070

出　　处：《中华内分泌代谢杂志》2019年第4期319-322,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：天津市科技计划项目、天津市慢性病防治科技重大专项项目(17ZXMFSY00200);天津市科技发展战略研究计划项目(18ZLZXZF00740);天津市中医、中西医结合科研课题(2017068、2017076).

摘　　要：入选2016年6月至2018年5月来本院内分泌科就诊的820例2型糖尿病患者,根据糖尿病视网膜病变(DR)发生情况分为DR组及非DR组,比较2组之间性别、年龄、糖尿病病程、吸烟情况、饮酒、糖尿病家族史、糖尿病发病年龄等指标。应用logistic回归分析探讨DR的危险因素。结果显示,入组患者有吸烟史患者387例(47.2%),不吸烟者433例(52.8%),合并有DR患者339例(41.3%),青少年期间有吸烟史患者129例,68例(52.7%)合并有DR。DR与非DR组患者在性别、年龄、体重指数、糖尿病家族史、饮酒史、HbA1C方面差异无统计学意义。Logistic回归分析发现高血压(OR=1.371,P=0.041)、糖尿病发病年龄<40岁(OR=1.526,P=0.028)、糖尿病病程(OR=2.653,P<0.001)及青少年吸烟史(OR=2.178,P<0.001)是DR发生的独立危险因素。A total of 820 patients who visited Endocrinology department in our hospital were enrolled in the study from June 2016 to May 2018. These patients were divided into diabetic retinopathy(DR)and non-diabetic retinopathy(NDR)groups according to the occurrence of DR. Factors such as gender, age, course of diabetes, smoking/drinking history, family history of diabetes, and onset age of diabetes were compared between the two groups, and logistic regression was used to analyze the risk factors of DR. The results showed that there were 387 smoker(47.2%) and 433 non-smoker(52.8%) in 820 tyge 2 diabetic patients, and 339(41.3%)patients were diagnosed with DR. There were no statistical differences in gender, age, body mass index, family history of diabetes, drinking history, and HbA1C between the two groups. Logistic regression analysis showed that duration of diabetes(OR=2.653, P<0.001), hypertension(OR=1.371, P=0.041), onset age of diabetes<40 years(OR=1.526, P=0.028), and adolescent smoking history(OR=2.178, P<0.001) were independent risk factors for DR.

关 键 词：青少年吸烟 糖尿病视网膜病变 糖尿病 2型 糖尿病发病年龄 

分 类 号：R587.2[医药卫生—内分泌]