200例酒精性肝病患者中医证候分布调查分析  

Investigation and Analysis of TCM Syndrome Distribution in 200 cases of alcoholic liver Disease

作　　者：傅克模[1] 谢圣影 莫耘松[1] 孟爱红[1] 高建华 程时峰[1] 戴东良 FU Ke-mu;XIE Sheng-ying;MO Yun-song(Department of Gastroenterology,Yuhang District Hospital oftraditional Chinese Medicine (Hangzhou Zhejiang 311106)China)

机构地区：[1]浙江省杭州市余杭区中医院消化内科,浙江杭州311106

出　　处：《中西医结合肝病杂志》2019年第2期133-136,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：浙江省卫生厅中医药科研基金资助课题(No.2015ZA176)

摘　　要：目的:探索酒精性肝病的中医证候分布特点,为酒精性肝病预防及治疗提供依据。方法:运用数据挖掘技术,以因子分析优化方案和回归分析方法,对200例酒精性肝病患者的证候分布进行统计分析。结果:通过本研究获得14种常见的酒精性肝病中医证候类型,分别为肝胃不和证(6.5%)、湿热内蕴证(10.0%)、肝胃积热证(7.5%)、脾虚湿困证(6.5%)、肝胃气滞证(3.5%)、肝胃气滞阴虚证(9.5%)、脾虚气滞证(8.0%)、肝胆湿热证(9.0%)、痰湿瘀滞证(6.0%)、湿困脾胃证(5.0%)、脾虚痰湿证(10.0%)、气虚气滞证(4.5%)、肝胃阴虚证(5.0%)、气滞痰凝证(9.0%)等。回归分析显示轻症酒精性肝病与气虚气滞证显著相关(P=0.007 <0.01);酒精性肝炎与湿热内蕴证(P=0.000<0.01)、肝胃气滞证(P=0.016<0.05)、痰湿瘀滞证(P=0.018<0.05)、脾虚气滞证(P=0.026 <0.05)显著相关;酒精性肝硬化与肝胆湿热证显著相关(P=0.01);酒精性脂肪肝优势相关证型不明显(P>0.05)。结论:以因子分析方法等数据挖掘技术所获得的证候分布,能够客观阐释中医证候分布特点,比较适用于中医证候的研究。Objective:To explore the characteristics of TCM syndromes distribution of alcoholic liver disease and provide basis for preven-tion and treatment of alcoholic liver disease. Methods:data mining technique was used to analyze the syndrome distribution of 200 patients with alcoholic liver disease by factor analysis and regression analysis. Results:through this study,14 common TCM syndromes of alcoholic liv-er disease were obtained,which were liver and stomach disharmony syndrome(6. 5%),dampness and heat accumulation syndrome(10. 0%), liver and stomach accumulation heat syndrome(7. 5%). Spleen deficiency syndrome(6. 5%),liver and stomach Qi stagnation syndrome (3. 5%),liver stomach qi stagnation syndrome(9. 5%),spleen syndrome(9. 5%) Deficiency of qi (8. 0%),liver and gallbladder damp-heat(9. 0%),phlegm and dampness stagnation(6. 0%),dampness to spleen and stomach(5. 0%),spleen deficiency and phlegm dampness (10. 0%),qi deficiency and qi stagnation(4. 5%). Liver and stomach yin deficiency syndrome(5. 0%),Qi stagnation phlegm coagulation syndrome(9. 0%) and so on. Regression analysis showed that alcoholic liver disease was significantly correlated with qi deficiency and qi stagnation syndrome(P = 0. 007),alcoholic hepatitis and damp-heat accumulation syndrome(P = 0. 000),liver and stomach Qi stagnation syndrome(P = 0. 016),phlegm dampness stagnation syndrome(P = 0. 016).(P = 0. 018),spleen deficiency and qi stagnation (P = 0. 026), alcoholic cirrhosis and liver and gallbladder dampness and heat (P = 0. 018),and alcoholic fatty liver syndrome were not significant (P > 0. 05). Conclusion:The distribution of syndromes obtained by data mining techniques such as factor analysis can objectively explain the dis-tribution characteristics of TCM syndromes and is more suitable for the study of TCM syndromes.

关 键 词：酒精性肝病 证候 因子分析 回归分析 

分 类 号：R259[医药卫生—中西医结合]