乙型肝炎病毒cccDNA与血清巨噬细胞移动抑制因子表达相关性的研究  

Correlation between expression of hepatitis B virus cccDNA and serum MIF in patients with hepatitis B

作　　者：张昌艳 陈智慧 梁建英 何蓉会 李双良 ZHANG Chang-yan;CHEN Zhi-hui;LIANG Jian-ying(Department of Infection, Nanchong Central Hospital (Nanchong Sichuan, 637000)China)

机构地区：[1]四川省南充市中心医院,四川南充637000

出　　处：《中西医结合肝病杂志》2019年第2期140-142,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨与研究(HBV)病毒cccDNA和血清巨噬细胞移动抑制因子(MIF)的表达相关性。方法:选择2015年2月到2018年7月,在我院接受治疗的78例乙型肝炎患者作为观察组,同期选择78例非肝炎感染患者作为对照组,对两组患者血清MIF、ALT、AST、TBil的表达进行检测,并进行HBV cccDNA表达分析。结果:观察组的血清ALT、TBiL、AST含量都显著高于对照组,对比差异显著(P<0.05)。观察组的血清MIF含量为(9.08±2.19)μg/L,显著高于对照组的(1.98±0.92)μg/L(t=8.272,P=0.000)。观察组的HBV cccDNA阳性率为50.0%,对照组为2.6%,观察组的HBV cccDNA阳性率显著高于对照组(P<0.05)。直线相关分析显示观察组的血清HBV cccDNA阳性率与血清ALT、TBiL、AST、MIF含量都呈现显著正相关性(P<0.05)。结论:乙肝患者体内血清MIF水平显著升高,也伴随有HBV cccDNA的阳性表达,两者存在显著的相关性。Objective:To investigate the correlation between the expression of hepatitis B(HBV) virus cccDNA and serum acrophage mi-gration inhibitory factor(MIF) in patients with hepatitis B. Methods:From February 2015 to July 2018,144 cases of patients with hepatitis B in our hospital were selected as the hepatitis B group,and the other 144 patients of not-HBV were selected as the control group at the same time. The serum samples and samples were collected in the two groups,the expression of serum MIF,ALT,AST,TBil,and HBV cccDNA ex- pression were given analysis. Results:The serum levels of ALT,TBiL and AST in the hepatitis B group were significantly higher than those in the control group,and the difference were significant(P < 0. 05). The content of serum MIF in hepatitis B group was 9. 08 ± 2. 19 g/L,which was obviously higher than 1. 98 ± 0. 92 g/L in the control group(t = 8. 272,P = 0. 000). The positive rate of HBV cccDNA in of hepatitis B group was 50. 0%,so that was 2. 6% in the control group. The positive rate of HBV cccDNA in of hepatitis B group was higher than that of control group(P < 0. 05). The linear correlation analysis showed that the positive rate of HBV cccDNA were positively correlated with serum ALT,TBiL,AST and MIF levels(P < 0. 05). Conclusion:The level of serum MIF in patients with hepatitis B is significantly increased,and is more accompanied by positive expression of HBV cccDNA,and there are significant correlation between them. Both of them have good clinical value.

关 键 词：乙型肝炎病毒 巨噬细胞移动抑制因子 HBV CCCDNA 相关性 

分 类 号：R512.62[医药卫生—内科学]