Infrared fluorescence imaging of infarcted hearts with A@S nanodots  

作　　者：Dirk H. Ortgies Angel Luis Garcia-Villalon Miriam Granado Sara Amor Emma Martin Rodriguez Harrisson DA Santos Jingke Yao Jorge Rubio-Retama Daniel Jaque 

机构地区：[1]Nanobiology Group, Instituto Ramon y Cajal de Investigacion Sanitaria, IRYCIS, Ctra. Colmenar km. 9.100, Madrid 28034, Spain [2]Fluorescence Imaging Group, Departamento de Fisica de Materiales - Facultad de Ciencias, Universidad Autonoma de Madrid, C/ Francisco Tomas y Valiente 7, Madrid 28049, Spain [3]Fluorescence Imaging Group, Departamento de Fisiologia - Facultad de Medicina, Avda. Arzobispo Morcillo 2, Universidad Autonoma de Madrid, Madrid 28029, Spain [4]Fluorescence Imaging Group, Departamento de Fisica Aplicada - Facultad de Ciencias, Universidad Autonoma de Madrid, C/ Francisco Tomas y Valiente 7, Madrid 28049, Spain [5]Grupo de Nano-Fotonica e Imagens, Instituto de Fisica, Universidade Federal de Alagoas, Maceio-AL 57072-900, Brazil [6]Departamento de Quimica Fisica en Ciencias Farmaceuticas, Facultad de Farmacia, Plaza de Ramon y Cajal, s/n, Universidad Complutense de Madrid, Madrid 28040, Spain

出　　处：《Nano Research》2019年第4期749-757,共9页纳米研究（英文版）

摘　　要：Ag2S nano dots have already bee n dem onstrated as promisi ng n ear-i nfrared (NIR-II, 1.0-1.45 pm) emitting nan oprobes with low toxicity, high penetration and high resolution for in vivo imaging of, for example, tumors and vasculature. In this work, we have systematically investigated the pote ntial applicati on of function alized Ag2S nano dots for accurate imaging of damaged myocardium tissues after a myocardial in farction in duced by either partial or global ischemia. Ag2S nano dots surface-function alized with the an giote nsin II peptide (ATI I) have show n over 10-fold enhanced binding efficiency to damaged tissues than non-specifically (PEG) functionalized Ag2S nanodots due to their interaction with the upregulated angiotensin II receptor type I (AT1R). It is demonstrated how the NIR-II images generated by ATII-functionalized Ag2S nanodots contain valuable information about the location and extension of damaged tissue in the myocardium allowing for a proper identification of the occluded artery as well as an in direct evaluati on of the damage level. The pote ntial applicati on of Ag2S nano dots in the n ear future for in vivo imaging of myocardial infarction was also corroborated by performing proof of concept whole body imaging experiments.

关 键 词：INFRARED IMAGING myocardial INFARCT AG2S NANODOTS biological windows LANGENDORFF heart 

分 类 号：O4[理学—物理]