2015年版《中国药典》一部含挥发油类中药的分类及其质量影响因素分析  

Classification of Chinese Medicines Containing Volatile Oil and Analysis of Quality Influencing Factors Based on Fist Part in Chinese Pharmacopoeia 2015 Edition

作　　者：焦姣姣 王雅琪[1,2] 熊优 杨园珍 伍振峰[2] 熊耀坤[2] 杨明[1,2] JIAO Jiao-jiao;WANG Ya-qi;XIONG You;YANG Yuan-zhen;WU Zhen-feng;XIONG Yao-kun;YANG Ming(Chengdu University of Traditional Chinese Medicine (TCM),Chengdu 611137,China;Jiangxi University of TCM, Nanchang 330004,China)

机构地区：[1]成都中医药大学,成都611137 [2]江西中医药大学,南昌330004

出　　处：《中国实验方剂学杂志》2019年第9期197-206,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81560657);江西省自然科学基金项目(20171BAB205099)

摘　　要：挥发油广泛分布于中药材中,含有丰富的化学成分,具有抗菌、抗炎、抗氧化、抗肿瘤、促透皮吸收、镇痛等多种药理活性。近年来,有关含挥发油类中药的研究日益增加,现今在临床医疗、保健、日用产品的开发等方面均已显示出广阔的应用前景。中药挥发油溶解性差、易挥发,性质不稳定。品种、采收季节、提取方法、炮制工艺、贮存条件等因素均会影响挥发油的成分与含量,进而直接影响其疗效、安全性和质量稳定性,因此控制挥发油含量显得尤为必要。现行2015年版《中国药典》在含挥发油类中药的质量控制方面做了许多规定,但却普遍未对挥发油的含量进行限度要求。鉴于中药挥发油良好的生物活性及质量标准尚不完善,本研究以2015年版《中国药典》一部为数据来源,通过文献研究与药典描述确定含挥发油类中药的种类;结合中药学知识,对196种含挥发油类中药的功能与主治、来源进行分类统计,辨析易混淆品种;综合分析挥发油的质量影响因素,总结其含量测定方法,为开发利用含挥发油类中药提供参考,为进一步加强和完善含挥发油类中药的质量标准奠定基础。Volatile oil is widely distributed in Chinese medicinal materials,which contains rich chemical compositions and has a variety of pharmacological activities such as anti-bacterial, anti-inflammatory, antioxidant,anti-tumor,transdermal absorption and antalgic activities, etc. In recent years, the research on the Chinese medicines containing volatile oil is increasing,showing a wide prospect of application in clinical medicine,health care,daily products development,etc. Volatile oil of traditional Chinese medicine has poor solubility,volatility and unstable properties. Factors such as species, harvesting seasons, extraction methods, processing technologies and storage conditions would affect the compositions and contents of volatile oil,thus directly affecting its efficacy,safety and quality stability. Hence,it is especially necessary to control the volatile oil content. The current 2015 edition of the Chinese Pharmacopoeia has made a lot of regulations on the quality control of Chinese medicines containing volatile oil,but generally does not provide the lowest and highest concentrations of volatile oil. As the volatile oil of traditional Chinese medicines has good biological activity and the quality standards are not yet perfect,this study would take the Fist Part of Chinese Pharmacopoeia 2015 Edition as the data source to determine the species of Chinese medicines containing volatile oils through literature research and pharmacopoeia description;the functions, indications, and sources of 196 kinds of traditional Chinese medicines containing volatile oil would be classified and the confusable species would be discriminated by using the Chinese pharmacy knowledge. In this study,the quality-influencing factors would be comprehensively analyzed and the content determination methods of volatile oil would be summarized to offer a reference for the development and application of Chinese medicinal materials containing volatile oil,as well as to lay the foundation for further reinforcing and improving their quality standar

关 键 词：含挥发油类中药 《中国药典》 分类 质量影响因素 含量测定 

分 类 号：R284.1[医药卫生—中药学] R289[医药卫生—中医学]