上海市松江区319对母婴麻疹和风疹抗体水平研究  

A study on measles and rubella antibody level in 319 pairs of mothers and infants in Songjiang District of Shanghai

作　　者：朱祺[1] 胡塔静[1] 沈静雯[1] 沈金花[1] 陈文花[1] 顾士康[1] 陆红梅[1] Zhu Qi;Hu Tajing;Shen Jingwen;Shen Jinhua;Chen Wenhua;Gu Shikang;Lu Hongmei(Immunoprophylaxis Department,Songjiang District Center for Disease Control and Prevention,Shanghai 201620,China)

机构地区：[1]上海市松江区疾病预防控制中心免疫预防科,201620

出　　处：《中华预防医学杂志》2019年第4期388-393,共6页Chinese Journal of Preventive Medicine

基　　金：上海市松江区科学技术攻关项目(15SJGG32).

摘　　要：目的了解上海市松江区产妇及新出生婴儿麻疹和风疹的抗体水平。方法于2016年11月至2017年2月,以松江区妇幼保健院符合纳入排除标准的319名产妇及其新生儿作为研究对象,采用ELISA检测研究对象血清的麻疹和风疹IgG抗体几何平均浓度(GMC),比较产妇和婴儿间风疹和麻疹抗体水平差异,采用Spearman相关分析研究产妇与婴儿间麻疹和风疹抗体水平的相关性。结果产妇分娩年龄为(29.71±4.25)岁,分娩时胎儿的胎龄为(39.06±1.30)周;麻疹抗体阳性率为82.5%(243/319),抗体保护率为43.3%(135/319),抗体GMC的M(QR)值为655.74(251.21~1299.02)mIU/ml;风疹抗体阳性率为61.1%(195/319),抗体GMC的M(QR)值为31.34(11.65~73.61)IU/ml。新生儿麻疹抗体阳性率为84.1%(270/321),抗体保护率为46.1%(148/321),GMC的M(QR)值为665.07(279.63~1544.07)mIU/ml;风疹抗体阳性率为69.5%(223/321),GMC的M(QR)值为40.30(16.12~98.48)IU/ml。产妇及婴儿间麻疹(Z=-14.64,P<0.001)、风疹(Z=-8.66,P<0.001)抗体GMC差异有统计学意义。产妇及婴儿间麻疹(r=0.76,P<0.001)、风疹(r=0.86,P<0.001)抗体水平存在正相关关系。结论母传麻疹和风疹抗体存在浓缩效应,新生儿麻疹和风疹抗体水平高于母亲,且随着母亲抗体水平的升高而升高。Objective To explore serum levels of measles and rubella IgG antibodies among mothers and infants.Methods According to the inclusion and exclusion criteria,we selected 319 puerperae and their infants in maternal hospitals of Songjiang district November 2016 to February 2017,venous blood were collected and serum measles and rubella IgG antibodies were measured using ELISA.To study the correlation between the level of measles and rubella antibodies in infants and mothers′by using the Spearman′s correlation analysis.Results The age at delivery was(29.71±4.25)years old;and the gestational age at delivery was(39.06±1.30)weeks.The positive rate and protection rate of measles antibody in puerperae were 82.5%(243/319)and 43.3%(135/319),the GMC[M(QR)]was 655.74(251.21-1 299.02)mIU/ml.The positive rate of rubella antibody in puerperae was 61.1%(195/319),the GMC[M(QR)]was 31.34(11.65-73.61)IU/ml.The positive rate and protection rate of measles antibody in infants were 84.1%(270/321)and 46.1%(148/321),the GMC[M(QR)]was 665.07(279.63-1 544.07)mIU/ml.The positive rate of rubella antibody in infants was 69.5%(223/321),the GMC[M(QR)]was 40.30(16.12-98.48)IU/ml.There was statistical difference in measles(Z=-14.64,P<0.001)and rubella(Z=-8.66,P<0.001)antibody levels between mothers and infants.There was positive correlation in measles(r=0.76,P<0.001)and rubella(r=0.86,P<0.001)antibody level between mothers and infants.Conclusion The maternal antibody of measles and rubella had a concentration effect.The level of measles and rubella antibodies in the infants was higher than that in the mothers′and increased with the increase of the level of measles and rubella antibodies in the mothers.

关 键 词：麻疹 风疹 母婴 抗体水平 

分 类 号：R511.1[医药卫生—内科学] R511.2[医药卫生—临床医学] R446.6