五氯柳胺混悬液对家兔的刺激性试验研究  

Experimental study on irritation of oxyclozanide suspension on rabbits

作　　者：董朕 张继瑜[1] 白玉彬 李晓婷 周绪正[1] 王玮玮 DONG Zhen;ZHANG Jiyu;BAI Yubin;LI Xiaoting;ZHOU Xuzheng;WANG Weiwei(Lanzhou Institute of Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sciences (CAAS),Key Laboratory o￡ Animal Drug production in Ministry of Agriculture,Key Laboratory of New Veterinary MedicineEngineering in Gansu Province,Lanzhou Gansu 730050,China;Gansu Agricultural University,College of Animal Medicine,Lanzhou Gansu 730070,China)

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所农业部兽用药物创制重点实验室甘肃省新兽药工程重点实验室,甘肃兰州730050 [2]甘肃农业大学动物医学院,甘肃兰州730070

出　　处：《中兽医医药杂志》2019年第2期62-64,共3页Journal of Traditional Chinese Veterinary Medicine

基　　金：国家科技支撑计划项目(2015BAD11B01-01);现代农业产业技术体系建设专项(CARS-37)

摘　　要：对家兔进行眼刺激性和皮肤刺激性试验,评价五氯柳胺混悬液的刺激性,给临床安全用药提供参考。眼刺激性试验选择日本大耳白兔8只,采用自体左右对照,五氯柳胺混悬液的平均刺激积分为1.13,其中4只试验兔在眼中滴入五氯柳胺混悬液后用温水冲洗,72 h后观察无刺激性反应;皮肤刺激性试验选择日本大耳白兔8只,分别为完好皮肤组、破损皮肤组,采用自体左右对照,72 h后,得到完整和破损皮肤组的刺激积分分别为0.25和0。结果表明,五氯柳胺混悬液对家兔眼睛及皮肤均无刺激性,临床用药安全。In order to evaluate the irritation of oxyclozanide suspension,to provide scientific basis for the safety of clinical administration and to eliminate or alleviate the irritation,eye irritation and skin irritation tests were carried out in rabbits. Eight Japanese white rabbits were selected for eye irritation test. Autogenous left and right controls were used. The average stimulus score of oxyclozanide suspension was 1.13,and 4 rabbits were washed with warm water after dropping oxyclozanide suspension into their eyes. No irritation was observed after 72 h;in skin irritation test,8 Japanese white rabbits were divided into intact skin group and damaged skin group. Autogenous left and right control were used. After 72 hours,the irritation scores of intact and damaged skin groups were 0.25 and 0,respectively. The results showed that oxyclozanide suspension had no irritation to the eyes and skin of rabbits and was safe for clinical use.

关 键 词：五氯柳胺混悬液 眼刺激性 皮肤刺激性 家兔 

分 类 号：S859.8[农业科学—临床兽医学]