IgG4相关性鼻腔鼻窦疾病的研究进展  

Advances in IgG4-related sinonasal diseases

作　　者：张媛[1,2] 朴颖实[3] 张罗[1,2] Zhang Yuan;Piao Yingshi;Zhang Luo(Department of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China;Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China;Department of Pathology, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China)

机构地区：[1]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科和过敏科,100730 [2]北京市耳鼻咽喉科研究所鼻病研究北京市重点实验室,100005 [3]首都医科大学附属北京同仁医院病理科,100730

出　　处：《中华耳鼻咽喉头颈外科杂志》2019年第3期227-231,共5页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

基　　金：国家重点研发计划(2016YFC0905200);教育部长江学者和创新团队发展计划(IRT13082);国家自然科学基金重点国际合作研究项目(81420108009);国家自然科学基金项目(816300195、81570895).

摘　　要：IgG4相关性疾病(IgG4-related disease,IgG4-RD)是近年认识的一种不同于普通慢性炎症和其他自身免疫性疾病的独立临床病理实体,常以瘤样病变为表现形式,可出现血清IgG4浓度升高,组织病理学以大量淋巴细胞和浆细胞浸润、席纹状纤维化和闭塞性静脉炎为主要特征。IgG4-RD发生于鼻腔鼻窦部位的研究国内外文献报道较少,缺乏大样本的研究数据,但正逐渐受到关注。本文拟从发病机制、临床特点、治疗和未来研究方向4个方面对IgG4相关性鼻腔鼻窦疾病作一综述。IgG4 related disease (IgG4-RD) is an independent clinical pathological entity which is different from common chronic inflammation and other autoimmune diseases in recent years. It often appears in the form of tumor like tissue-destructive lesions and may be accompanied by the increase of concentration of serum IgG4. Histopathology is characterized by a large number of lymphocytes and plasma cells infiltration, storiform fibrosis and occlusive phlebitis. The characteristics of IgG4-RD in nose and sinuses have not been widely investigated. The aim of the present study is to review the advances in IgG4 related sinonasal diseases from four aspects including pathogenesis, clinical features, treatment and future research directions.

关 键 词：IGG4相关性疾病 鼻 鼻窦 

分 类 号：R765[医药卫生—耳鼻咽喉科]