子宫内膜腺癌组织中cIAP、Caspase-7的表达及临床意义  

Expression and clinical significance of cIAP and Caspase-7 in endometrial adenocarcinoma

作　　者：黄露 刘燕华 林安平[1] HUANG Lu;LIU Yanhua;LIN Anping(Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China)

机构地区：[1]重庆医科大学附属第二医院妇产科,重庆400010

出　　处：《中国医药导报》2019年第11期89-92,共4页China Medical Herald

基　　金：重庆市科技计划项目(cstc2013jcyjA10099)

摘　　要：目的研究子宫内膜腺癌组织中凋亡抑制蛋白(cIAP)、半胱氨酸天冬氨酸蛋白酶7(Caspase-7)的表达情况及临床意义。方法采用免疫组织化学SP法对2015年1月～2017年12月于重庆医科大学附属第二医院接受刮宫和手术切除的80例子宫内膜腺癌组织、50例正常子宫内膜组织与50例子宫内膜不典型增生组织中cIAP、Caspase-7表达情况进行检查,并分析cIAP、Caspase-7表达与子宫内膜腺癌患者临床病理特征的关系,子宫内膜腺癌中c IAP、Caspase-7表达的相关性。结果子宫内膜腺癌组织cIAP阳性率高于子宫内膜不典型增生组织、子宫内膜正常组织,Caspase-7阳性率低于子宫内膜不典型增生组织、子宫内膜正常组织,差异均有统计学意义(P <0.05),子宫内膜不典型增生组织、子宫内膜正常组织c IAP阳性率、Caspase-7阳性率比较,差异无统计学意义(P> 0.05)。组织学分类G_1～G_2、FIGO分期Ⅰ～Ⅱ期、无淋巴结转移子宫内膜腺癌患者组织中的cIAP阳性率低于组织学分类G3、FIGO分期Ⅲ～Ⅳ期、有淋巴结转移患者,Caspase-7阳性率高于组织学分类G_3、FIGO分期Ⅲ～Ⅳ期、有淋巴结转移患者,差异均有统计学意义(P <0.05)。Spearman相关分析显示,子宫内膜腺癌组织中cIAP、Caspase-7的表达呈负相关(r=-0.843,P=0.039)。结论子宫内膜腺癌组织中cIAP存在明显高表达,而Caspase-7存在明显低表达,且两者均与子宫内膜腺癌患者的组织学分类、FIGO分期、淋巴结转移存在密切相关,其两者表达呈负相关,值得临床重点关注。Objective To study the expression and clinical significance of apoptosis inhibitory protein (cIAP) and caspase-7 in endometrial adenocarcinoma tissues. Methods The expression of cIAP and Caspase-7 in 80 cases of endometrial adenocarcinoma, 50 normal endometrium tissues and 50 cases of endometrial dysplasia were examined by immunohistochemical SP method in the Second Affiliated Hospital of Chongqing Medical University from January 2015 to December 2017, and the expression of cIAP, Caspase-7 and intrauterine were analyzed. The relationship between the clinicopathological characteristics and the expression of cIAP and Caspase-7 in endometrial adenocarcinoma. Results The positive rate of cIAP in endometrium adenocarcinoma was higher than that of endometrium atypical hyperplasia and normal endometrium. The positive rate of Caspase-7 was lower than that of endometrium atypical hyperplasia and normal endometrium (P < 0.05). The endometrium of endometrium was atypical hyperplasia tissue and endometrium was positive. There was no significant difference in cIAP positive rate and Caspase-7 positive rate between normal tissues (P > 0.05). The positive rate of cIAP in the tissues of G1 to G2, FIGO stage Ⅰ to Ⅱ, and non lymph node metastasis of endometrial adenocarcinoma was lower than that of histological classification G3, FIGO stage Ⅲ to Ⅳ, and lymph node metastasis. The positive rate of Caspase-7 was higher than that of histological classification G3, FIGO stage Ⅲ to Ⅳ, and lymph node metastasis, all of them was statistically significant (P < 0.05). Spearman correlation analysis showed that the expression of cIAP and Caspase-7 in endometrial adenocarcinoma was negatively correlated (r =-0.843, P = 0.039). Conclusion There is a significant high expression of cIAP in endometrial adenocarcinoma, while Caspase-7 has obvious low expression. Both of them is closely related to the histological classification, FIGO staging and lymph node metastasis of endometrial adenocarcinoma. The expression of them is negatively cor

关 键 词：子宫内膜腺癌 凋亡抑制蛋白质类 半胱氨酸天冬氨酸蛋白酶7 免疫组织化学法 临床病理特征 

分 类 号：R71[医药卫生—妇产科学]