斑秃与甲状腺自身免疫相关性的Meta分析  

A META-ANALYSIS OF THE ASSOCIATION BETWEEN ALOPECIA AREATA AND THYROID AUTOIMMUNITY

作　　者：马超[1] 郁博[1] 潘敏[1] 臧运书[1] MA Chao;YU Bo;PAN Min;ZANG Yunshu(Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China)

机构地区：[1]青岛大学附属医院皮肤科,山东青岛266003

出　　处：《青岛大学学报（医学版）》2019年第2期225-229,共5页Journal of Qingdao University(Medical Sciences)

基　　金：山东省医药卫生科技发展计划项目(2117WS636)

摘　　要：目的探讨斑秃与甲状腺自身免疫之间的相关性。方法以"斑秃"、"甲状腺"、"alopecia areata"或"alopecia circumscripta"、"thyroidgland"或"thyroid"为检索词,在万方数据库、中国生物医学数据库、中国知网、Pubmed、Embase、Cochrane中检索1974年1月1日—2016年4月20日期间发表、样本量≥20例的斑秃与甲状腺自身免疫相关性研究文献,应用Meta分析方法综合判断斑秃与甲状腺自身免疫的相关性,运用RevMan 5.3软件计算合并OR值和95%CI。结果入选的文献共有29篇,其中英文文献23篇,中文文献6篇,累计报告斑秃病人12 571人,健康对照790 182人。Meta分析结果显示,斑秃病人甲状腺自身抗体的阳性率高于健康组(OR=5.28,95%CI=4.01～6.95,P<0.05)。结论斑秃与甲状腺自身免疫之间存在相关性。Objective To investigate the association between alopecia areata and thyroid autoimmunity. Methods Using the search terms of "alopecia areata","alopecia circumscripta","thyroidgland" and "thyroid", Wanfang Data, CBM, CNKI, PubMed, Embase, and Cochrane were searched for the articles on the association between alopecia areata and thyroid autoimmunity, each with a sample size of ≥20 cases, published from January 1, 1974 to April 20, 2016. A Meta-analysis was then used to evaluate the association between alopecia areata and thyroid autoimmunity. The pooled odds ratio ( OR ) and 95% confidence interval ( CI ) were calculated by RevMan 5.3. Results A total of 29 articles were selected, including 23 in English and 6 in Chinese, in which 12 571 patients with alopecia areata, as well as 790 182 healthy controls, were reported. The Meta-analysis showed that the positive rate of thyroid autoimmune antibodies in the alopecia areata group was significantly higher than that in the healthy group ( OR =5.28,95% CI =4.01-6.95, P <0.05). Conclusion There is an association between alopecia areata and thyroid autoimmunity.

关 键 词：斑秃 甲状腺 自身免疫 META分析 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]