广州地区急性呼吸道感染住院儿童人博卡病毒流行病学分析  

Epidemiological analysis of human bocavirus in hospitalized children with acute respiratory tract in fection in Guangzhou

作　　者：蔡勇[1] 陈德晖[1] 刘文宽 梁文雅 刘升 周荣 王丹瑜 蒋惠 CAI Yong;CHEN Dehui;LIU Wenkuan;LIANG Wenya;LIU Sheng;ZHOU Rong;WANG Danyu;JIANG Hui(Department of Pediatrics,the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120,China)

机构地区：[1]广州医科大学附属第一医院儿科,广州 510120 [2]呼吸疾病国家重点实验室国家呼吸系统疾病临床医学研究中心广州呼吸健康研究院广州医科大学附属第一医院广州医科大学,广州 510230 [3]赣南医学院,江西 赣州 341000

出　　处：《实用医学杂志》2019年第7期1159-1161,共3页The Journal of Practical Medicine

基　　金：国家自然科学基金青年基金(编号:31500143);国家自然科学基金(编号:81770077);广州市科技计划项目(编号:201803040004)

摘　　要：目的了解广州地区急性呼吸道感染(ARI)住院儿童人博卡病毒(HBoV)的流行病学情况。方法取1 168例ARI患儿的鼻咽拭子标本,实时荧光RT-PCR法检测HBoV、人偏肺病毒(HMPV)、腺病毒(ADV)、呼吸道合胞病毒(RSV)、甲型流感病毒(infA)、乙型流感病毒(infB)、副流感病毒1、2、3、4(PIV1、2、3、4)、肠道病毒(EV)、冠状病毒(CoV)、鼻病毒(RHV)。结果HBoV检出率2.5%(29/1168)。HBoV与其他病毒混合检出率44.8%(13/29),以混合RSV最常见(46.2%,6/13)。不同年龄段患儿HBoV检出率分别为≤0.5岁1.9%,> 0.5岁且≤1岁4.2%,> 1岁且≤3岁3.1%,>3岁且≤6岁0.6%,>6岁0%,不同年龄段患儿HBoV检出率差异有统计学意义(χ2=10.073,P=0.039)。不同季节HBoV检出率分别为春季0.9%,夏季1.9%,秋季4.3%,冬季2.8%,不同季节检出率差异无统计学意义(χ2=6.91,P=0.075)。结论广州地区ARI住院患儿HBoV的检出率较低。HBoV常与其他病毒混合感染,其中以RSV最多见。0.5～3岁儿童是感染HBoV的重点人群。HBoV检查率无明显季节性。Objective To investigate the epidemiological analysis of human bocavirus(HBoV)in hospi talized children with acute respiratory tract infection(A RI)in Guangzhou.Methods Nasopharyngeal swab speci mens from 1,168 hospitalized children with ARI were collected.HBoV,adenovirus,respiratory syncytial virus,influenza virus,parainfluenza virus 1,2,3,4,intestinal virus,coronavirus,human metapneumovirus,rhinovirus were detected by real time fluorescence quantitative RT PCR.Results The positive rate of HBoV was 2.5%(29/1,168).HBoV and other viruses were detected simultaneously in 44.8%(13/29)of the children and RSV was the most common virus,accounting for 46.2%(6/13).Positive rate of HBoV in children of different ages was as following:1.9%in children younger than 0.5 year old,4.2%in those 0.5~1 year old,3.1%in those 1~3 years old,0.6%in those 3~6 years old and 0%in those older than 6.Positive rate of HBoV in children of different ages was statistically different(χ^2=10.073,P=0.039).Positive rate of HBoV in different seasons was as following:0.9%in spring,1.9%in summer,4.3%in autumn and 2.8%in winter,w hich showed no significant difference(χ^2=6.91,P=0.075).Conclusions HBoV is not the common pathogen of hospitalized children with ARI in Guangzhou.HBoV is often detected with other viruses simultaneously and RSV is the most common virus co infected with HBoV.Children aged 0.5~3 years are the key population with HBoV infection and there is no seasonal differ ence in HBoV infection rate.

关 键 词：急性呼吸道感染 广州 住院 儿童 博卡病毒 聚合酶链反应 

分 类 号：R725.1[医药卫生—儿科] R181.3[医药卫生—临床医学]