自体骨软骨移植治疗膝关节软骨缺损的长期随访  

Follow-up study on autogenous osteochondral transplantation for cartilage defect of knee joint

作　　者：刘嘉鑫 高永利 张广瑞 敏思聪 董海涛[3] 安丽萍[3] 韵向东[3] LIU Jia-xin;GAO Yong-li;ZHANG Guang-rui;MIN Si-cong;DONG Hai-tao;AN Li-ping;YUN Xiang-dong(Department of Orthopaedics,Lanzhou University Second Hospital,Lanzhou 730030,Gansu, China)

机构地区：[1]兰州大学第二临床学院,甘肃兰州730030 [2]合水县人民医院骨科,甘肃合水745400 [3]兰州大学第二医院骨科,甘肃兰州730030

出　　处：《中国骨伤》2019年第4期346-349,共4页China Journal of Orthopaedics and Traumatology

摘　　要：目的:探讨自体骨软骨移植治疗膝关节局限性软骨缺损的临床疗效。方法:选取2007年1月至2008年1月行自体骨软骨移植治疗膝关节软骨缺损的患者15例,其中男7例,女8例;年龄23～45岁。比较术前与术后10年KSS评分。结果:本组15例患者获得随访,时间10.0～10.7(10.2±0.3)年。KSS评分临床总分由术前的38.86±4.09上升至术后10年的85.07±2.19,功能评分由术前的3.33±4.88上升至术后10年的82.67±4.58,KSS总分由术前的42.20±7.84提高至术后10年的167.73±6.29(P<0.05);而膝关节稳定性比较差异无统计学意义(P>0.05)。所有随访患者并未出现其他并发症。结论:通过对自体骨软骨移植治疗膝关节软骨缺损患者的长期随访后发现,该治疗方式能够有效改善膝关节功能,减轻膝关节疼痛,是一种有效的修复膝关节软骨缺损的方法。Objective:To evaluate clinical effect of autologous osteochondral transplantation in treating localized knee cartilage defects.Methods:Fifteen patients with knee cartilage defects were treated by autologous osteochondral transplantation from January 2007 to January 2008,including 8 females and 7 males,aged from 23 to 45 years old.Preoperative and postoperative KSS score at 10 years were compared.Results:All patients were followed up for 10.0 to 10.7 years,with an average of(10.2±0.3)years.Clinical score of KSS was improved from 38.86±4.09 to 85.07±2.19 at 10 years after operation(P<0.05),functional score increased from 3.33±4.88 to 82.67±4.58 at 10 years after operation(P<0.05),KSS score was improved form 42.20±7.84 befor operation to 167.73±6.29 at 10 years after operation,and had statistical differences before and after operation.While there was no statistical difference in stability of knee joint(P>0.05).All patients had no other complications.Conclusion:Through long-term follow-up of patients with cartilage defect in knee treated by autologous bone cartilage transplantation showed that this method could effectively improve function of knee joint and alleviate pain.So it is an effective method for repair of osteochondral defect.

关 键 词：膝关节 软骨 骨移植 随访研究 

分 类 号：R681.3[医药卫生—骨科学]