2-二烷基膦基-2′,4′,6′-三异丙基-3,6-二甲氧基-1,1′-联苯的合成工艺  

Synthesis of 2-(di-alkylphosphino)-2′,4′,6′-triisopropyl-3,6-dimethoxy-1,1′-biphenyl

作　　者：余立明[1] 李云飞 刘婷婷 李永凯 张卫红[1] 陈杰英[1] YU Liming;LI Yunfei;LIU Tingting;LI Yongkai;ZHANG Weihong;CHEN Jieying(Institute of Chemistry Co.Ltd.,Henan Academy of Sciences,Zhengzhou 450002,China)

机构地区：[1]河南省科学院化学研究所有限公司,郑州450002

出　　处：《河南科学》2019年第4期541-544,共4页Henan Science

基　　金：河南省科技开放合作项目(182106000015);河南省科学院科研开发项目(18ZT03011;18ZS03009)

摘　　要：以1,4-二甲氧基-2-氟苯和2,4,6-三异丙基溴苯为原料合成2-碘-3,6-二甲氧基-2′,4′,6′-三异丙基-1,1′-联苯.在四氢呋喃和甲苯混合溶液中将联基碘代物制成格式试剂,在溴化亚铜和溴化锂的催化下,与二环己基氯化膦或二叔丁基氯化膦进行反应,分别以82%和75%的产率生成2-二环己基膦基-2′,4′,6′-三异丙基-3,6-二甲氧基-1,1′-联苯和2-二叔丁基膦基-2′,4′,6′-三异丙基-3,6-二甲氧基-1,1′-联苯,并对其结构进行了表征.2-(di-alkylphosphino)-2′,4′,6′-triisopropyl-3,6-dimethoxy-1,1′-biphenyl was synthesized with 1,4-dimethoxy-2-fluorobenzene and 2,4,6-triisopropylbromobenzene as the raw materials.The biphenyl iodide was then tranfered into the grignard reagent in tetrahydrofuran and toluene solution.After the reaction with dicyclichexylphosphine chloride or ditertbutylphosphine chloride under the catalysis of copper bromide and lithium bromide,the title product were got with the yield of 82% and 75%,and their structures were also characterized.

关 键 词：膦配体 叔丁基膦 环己基膦 联苯 合成 

分 类 号：O627.6[理学—有机化学]