高血压相关基因研究进展  

THE RESEARCH PROGRESS OF CORRELATION OF HYPERTENSION RELATED SNPS AMONG ELDERLYL PEOPLE

作　　者：康竹青 马宇虹[2] 皇甫卫忠[2] 田海燕[2] 袁向珍[2] 白图雅[1] 常福厚[1] KANG Zhu-qing;MA Yu-hong;HUANGFU Wei-zhong(Inner Mongolia Medical University,Inner Mongolia Hohhot 010059 China)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特010059 [2]内蒙古医科大学附属医院老年病科

出　　处：《内蒙古医科大学学报》2019年第2期218-220,224,共4页Journal of Inner Mongolia Medical University

基　　金：内蒙古自治区自然科学基金(ms2016(HL)0802)

摘　　要：老年高血压被认为是一种复杂的多基因病,是由环境因素及多种遗传因素相互共同作用的结果。基因单核苷酸多态性是指基因组内单个核苷酸的变异所引起的DNA序列的多态性。研究显示,SNP与抗高血压药物治疗效果具有相关性。本文对老年高血压相关基因单核甘酸与降压疗效相关性研究进展做一综述。Elderly Hypertension is a complex polygenic disease,is considered to be the results of genetic interaction of several variant genes and environmental factors.ACE,AGT and AT1R genes belong the rennin-angiotensin system,which is the main system of regulating blood pressure.Single Nucleotide Polymorphism(SNP)refers to the polymorphism of DNA sequence caused by mutation of single nucleotide in genome.There are some researches showed the connection between SNP and the hypertention.In this paper,Correlation of old age hypertension related gene mononuclear nucleotide and treatment effect is reviewed.

关 键 词：老年人 高血压 单核苷酸多态性 

分 类 号：R544.1[医药卫生—心血管疾病]