地佐辛所致恶心呕吐的危险因素分析和干预措施  

Risk factors of nausea and vomiting induced by dizosin and the intervention measures

作　　者：林文华 杨清杰[2] 曹畅[1] 史涛[1] Lin Wenhua;Yang Qingjie;Cao Chang;Shi Tao(Department of Pharmacy, 174th Hospital of PLA, Xiamen 361003, China;Department of Cardiothoracic Surgery, 174th Hospital of PLA, Xiamen 361003, China)

机构地区：[1]中国人民解放军第174医院药剂科,厦门361003 [2]中国人民解放军第174医院胸心外科,厦门361003

出　　处：《国际医药卫生导报》2019年第7期1067-1071,共5页International Medicine and Health Guidance News

摘　　要：目的分析使用地佐辛后出现恶心呕吐的人群特征,制定相应的临床干预措施,降低恶心呕吐发生率.方法将2016年7月至12月期间住院使用地佐辛的患者分为有恶心呕吐组和无恶心呕吐组,对比两组在疾病类别、性别、年龄、吸烟史、晕动症史、体质量、给药方式上是否有差异.明确恶心呕吐的危险因素,制定相应的临床干预措施.将2017年1月至6月期间住院拟使用地佐辛的患者随机分为试验组和对照组,对试验组采取临床干预并评估干预效果.结果采用多二元Logistic回归分析,恶心呕吐组和非恶心呕吐组在性别、年龄、吸烟史、晕动症史上差异有统计学意义(均P< 0.05),在疾病类别、体质量、给药方式上差异无统计学意义(均P> 0.05).经过干预,试验组恶心呕吐发生率明显低于对照组(7.0%比21.6%),且试验组中恶心呕吐患者焦虑评分明显低于对照组[(2.00±1.00)分比(4.18±1.40)分],二者差异均有统计学意义(均P< 0.05).结论女性、青年、不吸烟、有晕动症史的患者使用地佐辛后更容易出现恶心呕吐.通过预防性使用止吐药、心理疏导等临床干预可以有效降低地佐辛引起的恶心呕吐发生率,明显改善发生恶心呕吐的患者的焦虑情绪,值得在临床上推广.Objective To analyze the characteristics of patients with nausea and vomiting after using dizocin,and to develop some corresponding clinical intervention measures and reduce the occurrence of nausea and vomiting.Methods The patients who were hospitalized from July to December,2016 were divided into a nausea and vomiting group (NV group) and a non-nansea vomiting group(n-NV group).The differences in disease type,gender,age,smoking history,motion sickness history,weight,and medication administration were compared between these two groups.The risk factors of nausea and vomiting were identified,and corresponding clinical intervention measures were developed.A randomized controlled study was conducted on the patients who were hospitalized from January to June,2017;they were randomly divided into an experimental group and a control group.Clinical intervention was performed on the experimental group,and the intervention effect was evaluated.Results Analysis by binary multi-logistics regression showed that there were statistical differences in gender,age,smoking history,and motion sickness history (all P < 0.05)),but no in the categories of diseases,weight,and drug delivery methods (all P > 0.05) between the NV group and n-NV group.After the intervention,the incidence of nausea and vomiting was significantly lower in the experimental group than in the control group (7.0% vs.21.6%).Moreover,the anxiety score of the patients with nausea and vomiting in the experimental group was significantly lower than that in the control group [(2.00±1.00) vs.(4.18±1.40)].Both differences were statistically significant (both P < 0.05).Conclusion Female,young adults,non-smokers,and patients with a history of motion sickness are more prone to nausea and vomiting after using Dizocine.Through preventive clinical intervention,such as antiemetic drug and psychological counseling,the incidence of nausea and vomiting caused by diazoxin can be effectively reduced,and the anxiety of patients with nausea and vomiting can be significantly improved

关 键 词：地佐辛 恶心 呕吐 危险因素 干预 

分 类 号：R971.1[医药卫生—药品]