葡萄球菌肺炎患者早期特异性细胞因子研究  

Early cytokine expression analysis of patients with staphylococcus pneiinionia

作　　者：张雪倩 冯聪[1] 张曦木[1] 赵宇卓 刘昕[1] 赵春洪[1] 陈况 黎檀实[1] ZHANG Xue qian;FENG Cong;ZHANG Xi mu;ZHAO Yu zhuo;LIU Xin;ZHAO Chun hong;CHEN Kuang;LI Tan shi(Emergency Department, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China)

机构地区：[1]解放军总医院第一医学中心急诊科,北京100853 [2]解放军总医院第一医学中心肝胆外二科

出　　处：《中国急救复苏与灾害医学杂志》2019年第4期334-338,共5页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：国家自然科学基金(81701961);北京市科技新星计划项目(XX2018019);解放军总医院临床科研扶持基金(2017FC-WJFWZX-30).

摘　　要：目的探讨葡萄球菌肺炎患者发病早期体内细胞因子变化情况.方法选取解放军总医院第一医学中心急诊科2016年1月-2018年3月确诊的葡萄球菌肺炎患者19例为病例组和健康志愿者20例为对照组,使用高通量细胞因子试剂盒检测外周血11种细胞因子水平.结果葡萄球菌肺炎组与对照组性别组成、年龄组成、吸烟情况无差异(均P>0.05).葡萄球菌肺炎组IL-6、IFN-γ、MCP-l、TNF-α、TGF-α水平明显高于对照组(P<0.05),葡萄球菌肺炎组EGF水平低于对照组(P<0.05),两组lL-4、IL-8、IL-10、VEGF、FGF-2无统计学差异(P>0.05).结论IL-6、IFN-γ、MCP-l、TNF-α、EGF、TGF-α等细胞因子在葡萄球菌肺炎患者存在差异表达,检测细胞因子水平可为早期诊断葡萄球菌、评估患者病情变化提供依据.Objective To investigate the changes of the cytokine and in patients with staphylococcus pneumonia. Method 19 patients with staphylococcus pneumonia in the emergency department from Jun.2016 to Mar.2018 were chosen as the pneumonia group and 20 health adult were set as the control group. The levels of 11 cytokines were detected by using Human Cytokine /Chemokine Panel. Results There was no difference in sex, age and smoking between staphylococcal pneumonia group and control group (P>0.05).The levels of IL-6、IFN-γ、MCP-1 and TNF-α、 TGF-a of staphylococcal pneumonia group was higher than control group(P <0.05).The level of EGF was lower(P < 0.05).There was no significant difference in the level of IL-4、IL-8、VEGF、FGF-2 and IL-10. Conclusion The levels of IL-6 、IFN-γ、MCP-1、TNF-α、EGF、TGF-α were different.Detection of cytokine can help to assess changes in patients condition and provide early warning of prog no sis.

关 键 词：细菌性肺炎 葡萄球菌 细胞因子 

分 类 号：R563.1[医药卫生—呼吸系统]