细菌耐药质粒消除方法研究进展  

Progress on Elimination of Bacterial Resistance Plasmids

作　　者：朱利霞 王洪彬 史秋梅[1] 高光平[1] ZHU Li-xia;WANG Hong-bin;SHI Qiu-mei;GAO Guang-ping(Hebei Key Laboratory of Preventive Veterinary Medicine,Hebei Normal University of Science & Technology,Qinhuangdao,Hebei,066604,China)

机构地区：[1]河北科技师范学院河北省预防兽医学重点实验室,河北秦皇岛066604

出　　处：《动物医学进展》2019年第5期90-93,共4页Progress In Veterinary Medicine

基　　金：河北省自然科学基金项目(C2015407033);河北省教育厅项目(SLRC2017037);河北省高层次人才资助项目(A2016005046);河北科技师范学院科学研究基金项目

摘　　要：常见的病原微生物多重耐药性的增加以及多重耐药菌株的出现,给动物养殖业造成了巨大的经济损失。细菌的耐药性与其自身携带的耐药质粒关系密切。论文从细菌耐药现状,细菌的耐药性和耐药质粒的关系,耐药质粒的物理、化学、中草药消除方法这几个方面进行综述,旨在寻求一种安全有效的消除方法消除耐药质粒,为今后相关的研究提供参考。The increase of multi-drug resistance of common pathogenic microorganisms and the emergence of multi-drug resistant strains have caused lots of economic losses to animal breeding.From the aspect of gene research,the development of bacterial resistance is mainly related to the R plasmid.The R plasmid consists of two parts with different functions.The first is the drug resistance transfer factor,which acts like the F factor;the other is the drug resistance factor (RF),which determines drug resistance,namely,the loss of drug resistance must eliminate the R plasmid in the bacteria,and the probability of the spontaneous disappearance of the bacterial R plasmid in the normal living environment is particularly small.This article reviewed the status of bacterial drug resistance,the relationship between bacterial drug resistance and drug resistance plasmids,physical elimination methods,chemical methods,and Chinese herbal medicine methods.It aims to seek a safe and effective elimination method to eliminate drug resistant plasmids,and lay the foundation for future related research.

关 键 词：抗生素 耐药质粒 耐药性 质粒消除 

分 类 号：S852.61[农业科学—基础兽医学]