免疫营养成分ω-3多不饱和脂肪酸研究合作情况和研究主题剖析  

Cooperation and subject analysis of the research of ω-3 unsaturated fatty acids

作　　者：魏立明[1] 田金徽[2] 孙月[2] 焦海胜[1] Wei Liming;Tian Jinhui;Sun Yue;Jiao Haisheng(Department of Pharmacy,Lanzhou University Second Hospital,Lanzhou 730000,China)

机构地区：[1]兰州大学第二医院药学部,兰州730000 [2]兰州大学循证医学中心,兰州730000

出　　处：《中华临床营养杂志》2019年第1期33-41,共9页Chinese Journal of Clinical Nutrition

摘　　要：目的通过对我国发表的免疫营养成分ω-3多不饱和脂肪酸相关研究的合作情况、研究热点与前沿进行可视化分析,了解有关ω-3多不饱和脂肪酸的最新进展,为ω-3多不饱和脂肪酸研究者提供参考。方法计算机检索中国生物医学文献数据库,检索时间从建库检索至2017年12月31日。采用书目信息共现挖掘系统(BICOMS)对年代、作者、机构、省份和关键词信息进行抽取和整理,并生成共现矩阵;采用Ucinet6.0软件中的NetDraw绘制作者、机构、关键词和省份的社会网络分析图;采用gCLUTO2.0软件对主要关键词进行聚类分析。结果最终获得了1 165篇相关分析,30个省份,854个研究单位,3 789位作者参与发表。作者,机构和省份合作程度有待进一步加强。共获得1 016个具有实质意义的关键词,研究主题主要集中在多不饱和脂肪酸对糖尿病/心血管疾病/冠状动脉疾病等相关基因小鼠/大鼠细胞凋亡/血脂的作用,免疫营养成分改善肿瘤/炎症/脓毒症的meta分析,鱼油脂肪乳对肺炎/肺损伤等的白细胞介素/C反应蛋白的影响3个方面。结论我国ω-3多不饱和脂肪酸的相关研究数量逐年增长,但是主要集中于少数机构。省市,地区和机构合作需要进一步加强,研究主题仍需进一步拓展。Objective To learn the latest progress in the research of ω-3 unsaturated fatty acids and provide references for the related investigator through visualized analysis of the research of ω-3 unsaturated fatty acids published in our country. Methods China Biology Medicine disc was searched by computer from the beginning until December 31, 2017. Bibliographic Item Co-occurrence Mining System (BICOMS) was used to extract and summarize the data of age, author, organization, province and key words and to produce a co-occurrence matrix. NetDraw of Ucinet 6. 0 was employed to draw the social network diagram of the author, organization, province and key words. And cluster analysis of the key words was performed by gCLUTO 2.0. Results A total of 1 165 studies involving 30 provinces and cities, 854 research units, 3 789 authors and 1 016 significative key words were included. The cooperation of author, organization and province needed to be further strengthened. The study focused on 3 aspects: the effects of unsaturated fatty acids on apoptosis/lipid in mice/rats with related genes of diabetes/cardiovascular disease/coronary artery disease;meta-analysis of immunonutrition to improve tumor/inflammation/sepsis;effect of fish oil fat emulsion on interleukin/C reactive protein in pneumonia/lung injury. Conclusions The research of ω-3 unsaturated fatty acids develops rapidly in China, but it is mainly concentrated in a few centers of cooperation agencies. There is little cooperation among different provinces, cities, areas, and organizations and the research topics needs to be further expanded.

关 键 词：Ω-3多不饱和脂肪酸 免疫营养 合作情况 主题剖析 

分 类 号：R459.3[医药卫生—治疗学] G353.1[医药卫生—临床医学]