Tie2信号在血管炎中的抗炎作用  

The anti inflammatory effect of Tie2 signal in vasculitis

作　　者：吴晴[1] 李晓忠[2] 赵丽萍[1] Wu Qing;Li Xiaozhong;Zhao Liping(Department of Kidney, Rheumatology and Immunology, Wuxi Children's Hospital, Wuxi 214000, China;Department of Kidney and Rheumatology, Childrens Hospital Affiliated to Suzhou University, Suzhou215000, China)

机构地区：[1]无锡市儿童医院肾脏风湿免疫科,江苏无锡214000 [2]苏州大学附属儿童医院肾脏风湿科,江苏苏州215000

出　　处：《国际免疫学杂志》2019年第2期185-189,共5页International Journal of Immunology

基　　金：国家自然科学基金(81370787);江苏省临床医学科技专项(BL2014052).

摘　　要：血管炎是临床常见疾病,儿童多见的有过敏性紫癜(henoch schonlein purpura,HSP)、川崎病(Kawasaki disease,KD)和自身免疫病相关性血管炎如系统性红斑狼疮(systemic lupus erythematosus,SLE),幼年型特发性关节炎(juvenile idiopathic arthritis,JIA)等,炎症介质在血管炎的发病过程中起到关键作用.研究发现,酪氨酸蛋白激酶-2(tyrosine kinase-2,Tie2)信号系统激活后可抑制血管内皮细胞凋亡,维持血管稳定,减缓血管渗漏,从而达到抗炎作用.目前关于血管生成素及其受体Tie2在炎症反应中的作用的研究尚缺乏,以下将围绕血管生成素受体Tie2在血管炎中的研究进展作一综述.Vasculitis is common among children,which is often manifested as Henoch Schonlein purpu-ra(HSP),Kawasaki( KD)disease,systemic lupus erythematosus( SLE),and juvenile idiopathic arthritis (JIA). Inflammation plays a key role in the pathogenesis of vasculitis. It has been found that the activation of tyrosine kinase-2(Tie2)signaling system can inhibit vascular endothelial cell apoptosis,maintain vascular sta-bility,and reduce vascular leakage,thereby achieving anti-inflammatory effects. Until now,the role of angiopoie-tins and their receptor Tie2 in inflammatory response is still rare reported. Here we reviews the research about Tie2 signal in vasculitis.

关 键 词：酪氨酸蛋白激酶-2 抗炎 血管炎症 血管内皮保护 

分 类 号：R543[医药卫生—心血管疾病]