JAK/STAT信号通路与大肠癌及中医药调控  

JAK/STAT Signaling Pathway and Regulation of Colorectal Cancer and Traditional Chinese Medicine

作　　者：孔令豪 潘传芳[1] 沈克平[1] KONG Linghao;PAN Chuanfang;SHEN Keping(Longhua Hospital Affiliated of Shanghai University of Traditional Chinese Medicine,Shanghai 200030,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200030

出　　处：《中医药临床杂志》2019年第4期785-788,共4页Clinical Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(1173);龙华医院科技创新项目(CX201747)

摘　　要：JAK/STAT是人体内重要的信号通路之一,多种细胞因子和生长因子的细胞内信号转导和基因转录过程由其介导;JAK/STAT信号通路参与肿瘤细胞的增殖、分化、血管生成以及机体免疫调节等过程,因此肿瘤的发生发展和其异常表达及活化密切相关。文章初步分析JAK/STAT信号通路与大肠癌之间关联,以及在此基础上中医药对大肠癌的调控作用机制。Objective:JAK/STAT is one of the important signaling pathways in the human body.The intracellular signal transduction and gene transcription processes of various cytokines and growth factors are mediated by them.The JAK/STAT signaling pathway is involved in the process of tumor cell proliferation,differentiation,angiogenesis,and immune regulation.Therefore,the occurrence and development of tumors are closely related to their abnormal expression and activation.This paper preliminarily analyzes the relationship between JAK/STAT signaling pathway and colorectal cancer,and on this basis,the mechanism of regulation of colorectal cancer by traditional Chinese medicine.

关 键 词：大肠癌 信号通路 中医药调控 

分 类 号：R273[医药卫生—中西医结合]