pH/还原双敏感性纳米载药系统的研究进展  

Research progress in pH/redox dual sensitive nano-carrier system

作　　者：张志明 黄晨露 张琳华[1] 朱敦皖[1] Zhang Zhiming;Huang Chenlu;Zhang Linhua;Zhu Dunwan(Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Biomedical Materials, Tianjin 300192, China)

机构地区：[1]中国医学科学院北京协和医学院生物医学工程研究所,天津市生物医学材料重点实验室,天津300192

出　　处：《国际生物医学工程杂志》2019年第1期59-65,共7页International Journal of Biomedical Engineering

基　　金：国家自然科学基金面上项目(81671806,81571793);中国医学科学院医学与健康科技创新工程(2017-I2M-3-020,2017-I2M-4-001);天津市自然科学基金重点项目(15JCZDJC38300).

摘　　要：恶性肿瘤是仅次于心脑血管疾病致人死亡的第二大因素。化学治疗的方法中治疗肿瘤的药物通常有很强的毒副作用。常用的解决方法是利用纳米药物载体进行药物的递送,使药物到达肿瘤组织,从而杀伤肿瘤细胞;但是目前的多数药物载体在到达患处之前药物流失比较严重,难以实现药物的可控释放。多重刺激响应性纳米载药系统能很好地克服这些缺陷,使得药物的释放变得可控。对pH/还原双敏感性纳米载药系统研究是目前的一个热门领域。就近年来pH/还原双敏感性纳米载药系统的研究进展作一综述,以期为今后的相关研究提供借鉴。Malignant tumors are the second most important cause of death after cardiovascular and cerebrovascular diseases. Chemotherapeutic drugs for tumor treatment have strong toxic side effects. The common solution is to use nanoparticle as a carrier that can deliver drugs to tumor issues so as to kill the tumor cells. However, most of the current drug-carriers have a serious drug loss before reaching the tumor area, which makes the difficult control of drug release. Multi-stimulus responsive nano-carrier systems can overcome these drawbacks and make drug release controllable. pH/redox dual sensitive nano-carrier systems are currently hot research direction. In this paper, the research progress of pH/redox dual sensitive nano-carrier systems in recent years was reviewed in order to provide reference for relative researches.

关 键 词：肿瘤 pH/还原敏感 纳米载药 

分 类 号：R943[医药卫生—药剂学]