TET去甲基化酶在T细胞中的功能研究  

Function of TET demethylase in T cells

作　　者：邱颖 王红艳[1] QIU Ying;WANG Hong-Yan(Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China)

机构地区：[1]中国科学院上海生物化学与细胞生物学研究所,上海200031

出　　处：《中国免疫学杂志》2019年第8期897-901,共5页Chinese Journal of Immunology

摘　　要：DNA甲基化作为最重要的表观遗传修饰之一,在基因表达调控方面起重要作用。哺乳动物DNA甲基化主要发生在胞嘧啶第五位碳原子上,称为5-甲基胞嘧啶(5-methylcytosine,5mC). TET(Ten eleven translocation)家族蛋白氧化5-甲基胞嘧啶成为5-羟甲基胞嘧啶、5-醛基胞嘧啶和5-羧基胞嘧啶的一系列DNA去甲基化过程。TET家族蛋白和DNA去甲基化修饰在T细胞中的功能也逐渐被揭示。本文主要将近年研究TET去甲基化酶在T细胞中的功能进行总结和讨论。As one of the most important epigenetic modifications,DNA methylation plays an important role in gene expression regulation.Mammalian DNA methylation occurs mainly on the fifth carbon atom of cytosine,called 5-methylcytosine(5mC).TET(Ten Eleven Translocation)family proteins oxidize 5-methylcytosine to 5-hydroxymethylcytosine,5-aldehydecytosine and 5-carboxylcytosine.The functions of TET family proteins and DNA demethylation in T cells have also been revealed.In this review,we summarize and discuss the function of TET demethylase in CD4^+T cells.

关 键 词：DNA甲基化 TET去甲基化酶 CD4^+T辅助细胞 

分 类 号：R392[医药卫生—免疫学]