Quantum dots enhanced Cerenkov luminescence imaging  

作　　者：Chang-Ran Geng Yao Ai Xiao-Bin Tang Di-Yun Shu Chun-Hui Gong Ming-Hua Du Fa-Quan Ji 

机构地区：[1]Department of Nuclear Science and Engineering,Nanjing University of Aeronautics and Astronautics [2]Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions [3]Affiliated Hospital of Nanjing University of TCM

出　　处：《Nuclear Science and Techniques》2019年第5期9-13,共5页核技术（英文）

基　　金：supported in part by the Natural Science Foundation of Jiangsu Province(No.BK20180415);the National Natural Science Foundation of China(No.11805100);the Fundamental Research Funds for the Central Universities(No.NS2018041);the National Key Research and Development Program(Nos.2016YFE0103600and 2017YFC0107700)

摘　　要：Cerenkov luminescence imaging(CLI) has been widely investigated for biological imaging. However, the luminescence generated from Cerenkov effect is relatively weak and has poor penetration ability in biological tissues.These limitations consequently hindered the clinical translation of CLI. In this study, we proposed an in vitro experimental study for the demonstration of quantum dots(QDs) configurations affected by the improvement of the signal intensity of CLI. Results revealed that the optimal concentrations were 0.1 mg/mL and 0.25 mg/mL for the studied CdSe/ZnS QDs with fluorescence emission peaks of 580 nm and 660 nm, respectively. The detected optical signal intensity with long-wavelength emission QDs were stronger than those with short-wavelength emission QDs.This study illustrates an experiment to study the effects of concentrations and fluorescence emission peaks of QDs on an enhanced optical signal for the external detection of CLI.Cerenkov luminescence imaging(CLI) has been widely investigated for biological imaging. However, the luminescence generated from Cerenkov effect is relatively weak and has poor penetration ability in biological tissues.These limitations consequently hindered the clinical translation of CLI. In this study, we proposed an in vitro experimental study for the demonstration of quantum dots(QDs) configurations affected by the improvement of the signal intensity of CLI. Results revealed that the optimal concentrations were 0.1 mg/mL and 0.25 mg/mL for the studied CdSe/ZnS QDs with fluorescence emission peaks of 580 nm and 660 nm, respectively. The detected optical signal intensity with long-wavelength emission QDs were stronger than those with short-wavelength emission QDs.This study illustrates an experiment to study the effects of concentrations and fluorescence emission peaks of QDs on an enhanced optical signal for the external detection of CLI.

关 键 词：CERENKOV LUMINESCENCE IMAGING Quantum DOTS Optical signal Wavelength SHIFT 

分 类 号：TL[核科学技术]