GnRH治疗对特发性低促性腺激素性性腺功能减退症患者内分泌功能的相关性分析  

Correlation between GnRH therapy and endocrine function in patients with idiopathic hypogonadotropic hypogonadism

作　　者：孙敏[1] 伊国臻 SUN Min;YI Guozhen(Department of Clinical Laboratory,Qinghai Traditional Chinese Medicine Hospital,Xining,Qinghai 810000,China;Department of Clinical Laboratory,Hainan Prefecture People′sHospital,Hainan Prefecture,Qinghai 813099,China)

机构地区：[1]青海省中医院检验科,青海西宁810000 [2]青海省海南州人民医院检验科,青海海南813099

出　　处：《国际检验医学杂志》2019年第9期1111-1113,共3页International Journal of Laboratory Medicine

摘　　要：目的考察促性腺激素释放激素(GnRH)治疗对特发性低促性腺激素性性腺功能减退症患者内分泌功能影响。方法选取2006年8月至2017年7月间在青海中医院治疗的特发性低促性腺激素性性腺功能减退症患者22例,考察患者接受GnRH治疗后促性腺激素、性激素和骨代谢指标变化。结果治疗后患者的黄体生成素(LH)、睾酮(T)水平显著升高(P<0.05),但卵泡刺激素(FSH)水平差异无统计学意义(P>0.05)。治疗后碱性磷酸酶和骨钙素水平显著低于治疗前患者(P<0.05),但仅有2例患者出现骨质疏松。结论 GnRH治疗对特发性低促性腺激素性性腺功能减退症患者内分泌功能有良好调节作用,安全可靠,无明显不良反应。Objective To investigate the effect of gonadotropin-releasing hormone (GnRH) treatment on endocrine function in patients with idiopathic hypogonadotropic hypogonadism. Methods A total of 22 patients with idiopathic hypogonadotropic hypogonadism who were admitted to Qinghai Traditional Chinese Medicine Hospital from August 2006 to July 2017 were enrolled in the study.The changes of gonadotropin,sex hormones and bone metabolism indicators after GnRH treatment were investigated. Results The levels of luteinizing hormone (LH) and testosterone (T) increased significantly after treatment ( P <0.05), but there was no significant difference in the level of follicle stimulating hormone (FSH)( P >0.05). Alkaline phosphatase and osteocalcin levels after treatment were significantly lower than those before treatment ( P <0.05) but only two patients developed osteoporosis. Conclusion GnRH treatment has a good regulation effect on endocrine function in patients with idiopathic hypogonadotropic hypogonadism,and it is safe and reliable without obvious adverse reactions.

关 键 词：特发性低促性腺激素性性腺功能减退症 内分泌 促性腺激素释放激素 

分 类 号：S859.793[农业科学—临床兽医学] R816.6[农业科学—兽医学]