升清降浊通络明目方治疗糖尿病视网膜病变临床观察  

Clinical observation on the treatment of diabetic retinopathy with Shenqing Jiangzhuo Tongluo Mingmu prescription

作　　者：史薇[1] 张国立 薛秋慧 王小元[1] 魏学仿 张涛[1] 于爱忠[1] 刘亚男[1] 史增友 SHI Wei;ZHANG Guoli;XUE Qiuhui(Department of Ophthalmology, Fengrun District People's Hospital, Tangshan, Hebei 064000)

机构地区：[1]河北省唐山市丰润区人民医院眼科,河北唐山064000 [2]河北省唐山市丰润区人民医院内分泌科,河北唐山064000 [3]河北省唐山市丰润区人民医院中医科,河北唐山064000

出　　处：《河北中医》2019年第3期362-366,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局2018年度中医药类科研计划课题(编号:2018356)

摘　　要：目的观察升清降浊通络明目方治疗糖尿病视网膜病变(DR)的临床疗效。方法将200例DR患者按照随机数字表法分为2组。对照组100例予常规西药治疗;治疗组100例在对照组治疗基础上加服升清降浊通络明目方治疗。2组疗程均为8周,检测并比较2组治疗前后血糖[空腹血糖(FPG)、餐后2 h血糖(2 hPG)]、血脂[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]及血液流变学[全血黏度(高切、中切、低切)、血浆黏度、红细胞比容、纤维蛋白原]变化,比较2组治疗后眼底病变及视力改善情况。结果治疗组治疗后TC、TG、LDL-C、FPG、2 hPG均降低(P<0.05),HDL-C较治疗前升高(P<0.05);对照组治疗后FPG、2 hPG均降低(P<0.05)。治疗组治疗后TC、TG、LDL-C、FPG、2 hPG均低于对照组(P<0.05),HDL-C高于对照组(P<0.05)。治疗组治疗后全血黏度(高切、中切、低切)、血浆黏度及纤维蛋白原均降低(P<0.05),且均低于对照组(P<0.05)。对照组治疗后全血黏度(低切)明显降低(P<0.05)。治疗组眼底病变改善总有效率90%,明显高于对照组(62%,P<0.05);治疗组视力改善总有效率82%,明显高于对照组(57%,P<0.05)。结论升清降浊通络明目方治疗DR能改善患者血脂、血糖、血液流变学指标,改善眼底病变和视力,具有较好的疗效。Objective To observe the clinical efficacy of Shenqing Jiangzhuo Tongluo Mingmu prescription in the treatment of diabetic retinopathy (DR). Methods 200 DR patients were divided into two groups according to random number table method. 100 cases in control group were treated by conventional western medicine. 100 cases in treatment group were treated with by Shenqing Jiangzhuo Tongluo Mingmu prescription on the basis of the control group. Both groups were treated for 8 weeks. The changes of blood sugar [ fasting blood glucose (FPG) and postprandial 2-hour blood glucose (2 hPG)], blood lipid [ total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C)] and hemorheology [whole blood viscosity (high, medium and low shear), plasma viscosity, erythrocyte specific volume, fibrinogen ] before and after treatment were detected and compared. The changes of fundus diseases and visual acuity after treatment were compared between the two groups. Results After treatment, TC, TG, LDL-C, FPG and 2 hPG were decreased in the treatment group ( P <0.05), HDL-C was increased( P <0.05). After treatment, FPG and 2 hPG were decreased in the control group ( P <0.05). After treatment, TC, TG, LDL-C, FPG and 2 hPG in the treatment group were lower than those in the control group ( P <0.05), and HDL-C was higher than that in the control group ( P < 0.05 ). After treatment, the whole blood viscosity (high, medium and low shear), plasma viscosity and fibrinogen in the treatment group were all decreased ( P <0.05), and were lower than those in the control group ( P <0.05). The whole blood viscosity (low cut) was significantly decreased after treatment in the control group ( P <0.05). The total effective rate of fundus lesions in the treatment group was 90%, which was significantly higher than that in the control group (62%, P <0.05). The total effective rate of visual acuity improvement in the treatment group was 82%, which was significantly higher than that in the control

关 键 词：糖尿病视网膜病变 2型糖尿病 中药疗法 

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