3D打印醋酸地塞米松口腔贴片的辅料筛选及体外评价  

Excipient screening and in vitro evaluation of 3D printing dexamethasone acetate oral patch

作　　者：黄家琪 郑康钰 何妙珊 班俊峰 林威 皮雪莹 陈培鸿 吕竹芬 陈燕忠 HUANG Jiaqi;ZHENG Kangyu;HE Miaoshan;BAN Juanfeng;LIN Wei;PI Xueying;CHEN Peihong;LYU Zhufen;CHEN Yanzhong(Key Laboratory of Advanced Drug Delivery of Guangdong Province,Guangzhou 510006,China;Department of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China;Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System,Guangzhou 510006,China)

机构地区：[1]广东省药物新剂型重点实验室,广东广州510006 [2]广东药科大学药学院,广东广州510006 [3]广东省局部精准药物递药制剂工程技术研究中心,广东广州510006

出　　处：《广东药科大学学报》2019年第2期164-168,共5页Journal of Guangdong Pharmaceutical University

基　　金：广州市科创委项目--产学协同创新重大专项资助项目(20170402199)

摘　　要：目的采用3D打印技术制备个体化醋酸地塞米松口腔贴片。方法以体外黏附力、黏附时间及3 h累积释放度为评价指标,筛选醋酸地塞米松口腔贴片填充剂、黏附剂和黏附剂用量。结果以最优处方制备3种不同半径(3、4、5 mm)的口腔贴片,体外黏附力分别为(1.46±0.08)N/cm^2、(2.03±0.94)N/cm^2、(2.25±0.19)N/cm^2,体外黏附时长分别为(4.06±0.76)h、(4.87±0.59) h和(5.64±0.63) h,3 h累计释放度分别为(93.61±1.07)%、(92.73±1.34)%和(93.57±1.63)%。结论通过单因素筛选出最优处方制备的3种不同规格口腔贴片体外评价指标均达到设计要求。Objective To prepare individualized dexamethasone acetate oral patch by 3D printing technology.Methods The in vitro adhesion,adhesion time and cumulative release of 3 hours were used as evaluation indexes to evaluate the dosage of dexamethasone acetate oral patch filler,adhesive and adhesive dosage.Results Three kinds of oral patches with different radii (3 mm,4 mm,5 mm) were prepared with the optimal prescription.The in vitro adhesion was (1.46±0.08) N/cm^2,(2.03±0.94) N/cm^2,(2.25±0.19) N/cm^2,respectively.The adhesion durations were (4.06±0.76) h,(4.87±0.59) h,(5.64±0.63) h,respectively,and the cumulative release rate at 3 h was (93.61±1.07)%,(92.73±1.34)%,and (93.57± 1.63)%,respectively.Conclusion The in vitro evaluation indexes of three different specifications of oral patches prepared by single factor brush selection have reached the design requirements.

关 键 词：3D打印技术 醋酸地塞米松 口腔贴片 体外黏附力 体外黏附时间 释放度 

分 类 号：R946.4[医药卫生—药剂学]