肾炎康复片联合激素治疗儿童紫癜性肾炎的临床疗效及安全性分析  

Clinical efficacy and safety of Shenyankangfupian combined with hormones in the treatment of children with Henoch-Sch?nlein purpura nephritis

作　　者：霍丽娇 王琨 柏金秀[3] 马腾腾 魏继红[3] HUO Lijiao;WANG Kun;BAI Jinxiu;MA Tengteng;WEI Jihong(Medical College of Hebei University,Baoding 071000,China;Department of Pediatrics,the Eighty-second Group Military Hospital of PLA,Baoding 071000,China;Department of Pediatrics of Affiliated Hospital of Hebei University,Baoding 071000,China)

机构地区：[1]河北大学医学院,河北保定071000 [2]陆军第八十二集团军医院儿科,河北保定071000 [3]河北大学附属医院儿科,河北保定071000

出　　处：《医学研究与教育》2019年第2期28-32,共5页Medical Research and Education

摘　　要：目的分析肾炎康复片联合糖皮质激素治疗儿童紫癜性肾炎的临床疗效及安全性。方法 2018年1月至11月河北大学附属医院收治的80例紫癜性肾炎患儿为实验对象,依据入院先后顺序分为对照组(n=39)、观察组(n=41), 2组患儿均开展抗过敏等相关对症治疗,对照组给予糖皮质激素治疗,观察组在对照组的基础上给予肾炎康复片治疗,对比2组患儿的临床效果、临床症状消退时间、 24 h尿蛋白定量、血清IgA水平及不良反应。结果对照组和观察组比较临床疗效差异有统计学意义(Z=1.688,P=0.046);与对照组比较,观察组患儿的临床症状消退时间较短(P<0.05);治疗前,与对照组比较,观察组患儿的24 h尿蛋白定量及血清IgA水平差异无统计学意义(P>0.05);治疗后,与对照组比较,观察组患儿的24 h尿蛋白定量及血清IgA水平改善明显;与对照组不良反应发生率(20.51%)比较,实验组(2.45%)较低(P<0.05)。结论针对紫癜性肾炎患儿在糖皮质激素治疗的基础上给予肾炎康复片治疗,在提升治疗效果的同时减少不良反应,改善24 h尿蛋白定量、血清IgA水平,缩短临床症状消退时间。Objective To analyze the clinical efficacy and safety of Shenya nkangfupian combined with glucocorticoid in the treatment of children with Henoch-Sch nlein purpura nephritis. Methods 80 children with Henoch-Sch nlein purpura nephritis admitted to Affiliated Hospital of Hebei University from January 2018 to November 2018 were divided into control group ( n =39) and observation group ( n =41) according to the order of admission. The patients of the two groups were given symptomatic treatment such as anti-allergy, the patients in the control group were given glucocorticoid therapy, and the patients in the observation group were given Shenyankangfupian on the basis of the control group, and the treating. results of the two groups were compared. The clinical effect, clinical symptoms subsidence time, urinary protein excretion in 24-hour collections, serum IgA and adverse reactions of the patients were examined. Results There was statistically significant difference between the control group and the observation group in the clinical effect( Z=1.688, P =0.046). Compared with the control group, the clinical symptom regression time of the observation group was shortened ( P <0.05). Before treatment, compared with the control group, there was no statistically significant difference in the urinary protein excretion in 24-hour collections and serum IgA level of the observation group ( P >0.05). After treatment, compared with the control group, the urinary protein excretion in 24-hour collections and serum IgA level of the observation group were significantly improved. Compared with the control group (20.51%), the incidence of adverse reactions in the experimental group (2.45%) was reduced ( P <0.05). Conclusion Shenyankangfupian given to children with Henoch-Sch nlein purpura nephritis on the basis of glucocorticoid therapy can improve the therapeutic effect and reduce adverse reactions, improve urinary protein excretion in 24-hour collections and serum IgA shorten the time of clinical symptoms subsidence.

关 键 词：肾炎康复片 糖皮质激素 儿童紫癜性肾炎 临床疗效 安全性 

分 类 号：R72[医药卫生—儿科]