类固醇糖尿病相关致病因素的研究进展  

Research Progress of Related Pathogenic Factors for Steroid-induced Diabetes Mellitus

作　　者：王嘉祺 梁伟时 李硕峰 门秀丽 WANG Jiaqi;LIANG Weishi;LI Shuofeng;MEN Xiuli(Basic Medical CollegeClinical Medical College ,Hebei Tangshan 063210,China;Basic Medical College North China University of Science and Technology,Hebei Tangshan 063210,China)

机构地区：[1]华北理工大学基础医学院,河北唐山063210 [2]华北理工大学临床医学院,河北唐山063210

出　　处：《中国医药导刊》2019年第4期212-216,共5页Chinese Journal of Medicinal Guide

基　　金：国家自然科学基金项目(项目编号:81370918;项目名称:GSK-3β在糖皮质激素诱导胰岛β细胞功能衰退中的作用及分子机制研究)

摘　　要：类固醇糖尿病(steroid-induced diabetes mellitus,SDM)是一种继发性糖尿病,其发病主要与肾上腺皮质的糖皮质激素异常分泌或应用过量的外源性糖皮质激素有关,类似于2型糖尿病,SDM的主要致病机制包括胰岛β细胞功能障碍和胰岛素抵抗(insulin resistance, IR)。SDM具有明显的流行病学特征,发病率因致病因素的差异而不同,其引起的血糖水平升高有可逆性。了解其发病机制和相应的致病因素,对预防SDM的发生和对症高效治疗SDM均有十分重要的意义。Steroid-induce diabetes mellitus (SDM) is a type of secondary diabetes mellitus,which is mainly associated with abnormal secretion of glucocorticoids from the adrenal cortex or excessive application of exogenous glucocorticoids.Similar to type 2 diabetes,the main pathogenesis of SDM includes dysfunction of pancreatic β cells and insulin resistance (IR).SDM has obvious epidemiological characteristics,the incidence of SDM varies with the pathogenic factors,and the blood glucose of high level increase caused by SDM is reversible.Understanding its pathogenesis and corresponding pathogenic factors is of great significance for preventing the occurrence of SDM and effectively treating SDM.

关 键 词：类固醇糖尿病 糖皮质激素 胰岛素抵抗 胰岛Β细胞 

分 类 号：R587.1[医药卫生—内分泌]