近红外光谱法同时检测复方卡托普利片中卡托普利和氢氯噻嗪的含量  

Simultaneous Determination of Captopril and Hydrochlorothiazide in Compound Captopril Tablets by Near Infrared Spectroscopy

作　　者：林敏玲 吴定丽 吴云妹 彭梦侠[1] LIN Minling;WU Dingli;WU Yunmei;PENG Mengxia(School of Chemistry and Environment, Jiaying University, Meizhou 514015 China)

机构地区：[1]嘉应学院化学与环境学院,广东梅州514015

出　　处：《化工技术与开发》2019年第5期46-50,共5页Technology & Development of Chemical Industry

基　　金：2018年省级大学生创新创业训练计划项目(201810582067)

摘　　要：以高效液相色谱测定出的复方卡托普利片中卡托普利和氢氯噻嗪的含量为标准,将化学计量学与近红外光谱技术相结合,分别建立复方卡托普利药片和药粉的定量分析模型。对药片模型和药粉模型的预测结果进行了比较,结果表明,药粉模型预测结果的准确度略优于药片模型。本方法操作简单,实验结果准确可靠,可同时快速检测复方卡托普利片中卡托普利和氢氯噻嗪的含量。The content of captopril and hydrochlorothiazide in compound captopril tablets was determined by HPLC. The quantitative analysis model of compound captopril tablets and powders was established by combining chemometrics with near-infrared spectroscopy. The prediction results of the tablet model and the powder model were compared. The results showed that accuracy of the prediction results of the powder model was slightly better than the tablet model. The method of operation was simple, the test result was accurate and reliable, and the content of captopril and hydrochlorothiazide in the compound captopril tablet could be quickly detected at the same time.

关 键 词：近红外光谱 化学计量学 快速检测 卡托普利 氢氯噻嗪 

分 类 号：O657.33[理学—分析化学]