类风湿因子和抗环瓜氨酸多肽抗体阳性人群维生素D水平分析  

Vitamin D level of population with positive anti-rheumatoid factor and anti-cyclic citrulline polypeptide antibody

作　　者：黄土艺 李雪[2] 张松 吴记平[2] HUANG Tu-yi;LI Xue;ZHANG Song;WU Ji-ping(Health Management Centre,Dongguan People′sHospital,Dongguan 523000,Guangdong Province,China;Department of Rheumatology,Dongguan People′s Hospital,Dongguan523000,GuangdongProvince,China;Department of Rheumatology,Guangzhou Women andChildren′s Center,Guangzhou 510623,Guangdong Province,China)

机构地区：[1]东莞市人民医院健康管理中心,广东东莞523000 [2]东莞市人民医院风湿科,广东东莞523000 [3]广州市妇女儿童中心风湿科,广东广州510623

出　　处：《新乡医学院学报》2019年第5期440-442,共3页Journal of Xinxiang Medical University

基　　金：广东省医学科学技术研究基金青年项目(编号:A2016163)

摘　　要：目的探讨类风湿因子(RF)和抗环瓜氨酸多肽(CCP)抗体阳性人群维生素D水平。方法选择2015年1月至2017年12月在东莞市人民医院进行体检的3 082例人群中RF阳性(≥20 kU·L^(-1))和(或)抗-CCP抗体阳性(≥5 kU·L^(-1))非类风湿关节炎(RA)个体为观察组(n=87),另选择同期行体检的RF和抗-CCP抗体水平正常健康个体90例为对照组,同期住院治疗的70例初诊为RA患者为RA组。比较3组受试者血清RF、抗-CCP抗体、25-羟基维生素D[25(OH) D]的水平。结果 3 082例体检人群中,RF阳性率为2.6%(80/3 082),抗-CCP抗体阳性率为0.6%(20/3 082)。RA组、观察组受试者血清RF、抗-CCP抗体水平显著高于对照组(P<0.05);观察组受试者血清RF、抗-CCP抗体水平低于RA组(P<0.05)。RA组、观察组受试者血清25(OH) D水平显著低于对照组(P<0.05);观察组受试者血清25(OH) D水平高于RA组(P<0.05)。观察组、RA组受试者维生素D缺乏率高于对照组(χ~2=4.227、9.753,P<0.05)。观察组受试者维生素D缺乏率与RA组比较差异无统计学意义(χ~2=1.370,P>0.05)。结论RF阳性、抗-CCP抗体阳性人群血清25(OH) D水平低于健康人群高于RA患者,维生素D缺乏明显。Objective To investigate the level of vitamin D in health examination population with positive anti-rheumatoid factor (RF) and anti-cyclic citrulline polypeptide(anti-CCP) antibody. Methods Among3 082 health examination peoples in Dongguan People′s Hospital from January2015 and December2017,the subjects without rheumatoid arthritis(RA) whose serum RF(≥20 kU·L^-1 ) and/or anti-CCP antibody(≥5 kU·L^-1 ) was positive were selected as observation group( n =87).Ninety health examination peoples with normal serum RF and/or anti-CCP antibody level were selected as control group,and seventy patients with RA were selected as RA group.The levels of the serum RF,anti-CCP antibody and25- hydroxyvitamin D[25(OH)D] were compared among the three groups. Results Among3 082 health examination peoples,the RF positive rate was2.6%(80/3 082) and the anti-CCP antibody positive rate was 0.6%(20/3 082 ).The levels of serum RF and anti-CCP antibody in the observation group and RA group were higher than those in the control group( P <0.05).The levels of serum RF and anti-CCP antibody in the observation group were lower than those in the RA group( P <0.05).The serum25(OH)D level in the observation group and RA group was lower than that in the control group( P <0.05).The level of serum25(OH)D in the observation group was higher than that in the RA group ( P <0.05).The vitamin D deficiency rate in the observation group and RA group was higher than that in the control group(χ^2=4.227,9.753;P < 0.05).There was no significant difference in vitamin D deficiency rate between the observation group and the RA group(χ^2=1.370, P >0.05). Conclusion The level of serum25(OH)D in people who are RF positive and/or anti-CCP antibody positive is lower than healthy people and higher than RA people,and vitamin D deficiency is obvious.

关 键 词：类风湿因子 抗环瓜氨酸抗体 25羟基维生素D 

分 类 号：R681[医药卫生—骨科学]