衣原体包涵体膜蛋白的结构特征及生物学功能研究进展  

Research progress on the structural characteristic and biological function of chlamydial inclusion membrane proteins

作　　者：肖健 王川[1] 吴移谋[1] XIAO Jian;WANG Chuan;WU Yi-mou(Institute of Pathogenic Biology,University of South China,Hengyang 421001,China)

机构地区：[1]南华大学病原生物学研究所,衡阳421001

出　　处：《中国人兽共患病学报》2019年第4期338-344,共7页Chinese Journal of Zoonoses

基　　金：鹦鹉热衣原体质粒蛋白生物学特性及功能研究(No.81671986)~~

摘　　要：包涵体膜蛋白是一类由衣原体分泌并被转运至包涵体膜的衣原体特异性蛋白。进入宿主细胞后,衣原体即可分泌大量蛋白对包涵体膜进行修饰,这类蛋白位于衣原体-宿主细胞界面处,因此可在维持包涵体稳定性、衣原体营养摄取及与宿主细胞发生相互作用的过程中发挥重要功能。本文就包涵体膜蛋白的结构特征及生物学功能研究进展进行了综述,以期更深入了解这种衣原体效应蛋白。Inclusion membrane proteins (Inc proteins) are a subset of Chlamydiae -specific proteins that are secreted by the Chlamydia and are localized in inclusion membrane.Entering the host cell,chlamydia can secrete plenty of proteins to modify the inclusion membrane.The inclusion membrane is the interface between the Chlamydia and the host.Inc proteins are expected to play an important role in maintaining the stability of inclusion,in the uptake of nutrients required for Chlamydia,and in the interaction with host cells.This article briefly reviewed the research progress on Inc proteins in order to gain a deeper understanding of their structural characteristics and biological functions.

关 键 词：衣原体 包涵体膜蛋白 生物学功能 

分 类 号：R374[医药卫生—病原生物学]