铜催化α,β-不饱和羧酸与ICH2CF3的脱羧偶联反应  

Copper-catalyzed Decarboxylative Cross-coupling of α,β-Unsaturated Carboxylic Acid with ICH2CF3

作　　者：单长领 黄焰根[1] SHAN Chang-ling;HUANG Yan-gen(College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China)

机构地区：[1]东华大学化学化工与生物工程学院

出　　处：《合成化学》2019年第5期362-367,共6页Chinese Journal of Synthetic Chemistry

基　　金：中央高校基本科研业务费专项资金资助项目

摘　　要：铜催化下,以CH 3 CN和HOAc为混合溶剂,α,β-不饱和羧酸与1,1,1-三氟-2-碘乙烷(ICH 2 CF 3 )发生脱羧偶联反应合成了一系列三氟乙基取代烯烃,其结构经 1 H NMR、 13 C NMR和HR-MS确证。 19 F NMR分析显示该反应具有优良的立体选择性( E/Z 最高为99/1),分离收率最高达82%。A series of trifluoroethylated alkenes were synthesized by copper-catalyzed decarboxylative coupling of α,β-unsaturated carboxylic acids and 1,1,1-trifluoro-2-iodoethane using CH 3 CN and acetic acid as a combined solvent. The structures were characterized by 1 H NMR, 13 C NMR and HR-MS. 19 F NMR analyses indicated that the reaction has good stereoselectivity( E/Z was up to 99/1), and the isolated yield was up to 82%.

关 键 词：α β-不饱和羧酸 1 1 1-三氟-2-碘乙烷 脱羧偶联 三氟乙基取代烯烃 铜催化 合成 

分 类 号：O623.731[理学—有机化学] O623.83[理学—化学]