常温下扑热息痛的常规、半常量及微型制备方法初探  

Normal,Semi Constant and Mini Preparation Methods of Paracetamol at Room Temperature

作　　者：覃其品 蒙昌宇[1] 邹碧群[2] QIN Qi-pin;MENG Chang-yu;ZOU Bi-qun(Yulin Normal University,Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology,School of Chemistry and Food Science,Yulin,Guangxi 537000,China;Department of Chemistry and Pharmacy,Guilin Normal College,Guilin,Guangxi 541001,China)

机构地区：[1]玉林师范学院广西农产资源化学与生物技术重点实验室化学与食品科学学院,广西玉林537000 [2]桂林师范高等专科学校化学与药学系,广西桂林541001

出　　处：《教育教学论坛》2019年第22期272-273,共2页Education And Teaching Forum

基　　金：广西高等教育本科教学改革工程项目(2018GJA243)资助

摘　　要：本文介绍了在常温下扑热息痛常规、半常量及微型化制备方法的实验比较,即以对氨基苯酚为原料,以二氯甲烷为反应溶剂,在常温下进行常规、半常量及微型化三种方法合成了扑热息痛。实验结果表明,微型法优于常规法和半常量法。常温下微型化合成扑热息痛条件温和,达到反应终点时间仅为15分钟,收率为96.03%,有效地提高了实验效率。The preparation methods of paracetamol by conventional,semi-constant and miniaturized methods at room temperature were introduced.Paracetamol was synthesized from p-aminophenol and dichloromethane by conventional,semi-constant and miniaturized methods at room temperature.The experimental results show that the micro method is better than the conventional and semi constant methods.The reaction time was only 15 minutes and the yield was 96.03%.The experimental efficiency was improved effectively.

关 键 词：扑热息痛 常规 半常规 微型制备 常温 

分 类 号：G642.0[文化科学—高等教育学]