pH响应性树枝状聚合物-金纳米粒子复合药物载体的制备  

Preparation of Dendrimer-gold Nanoparticle Composites for pH Responsive Drug Delivery

作　　者：朱钦富 胡可珍 李小杰 陈明清 .ZHU Qinfu;HU Kezhen;LI Xiaojie;CHEN Mingqing(Key Laboratory of Synthetic and Biological Colloid of the Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 2141221, China)

机构地区：[1]江南大学化学与材料工程学院合成与生物胶体教育部重点实验室,无锡214122

出　　处：《高等学校化学学报》2019年第5期1065-1070,共6页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21504032);中央高校基本科研业务费专项资金(批准号:JUSRP115A07)资助~~

摘　　要：以表面接枝聚乙二醇链的聚酰胺胺树枝状聚合物(PEG-PAMAM)为纳米载体,在其内部空腔包覆金纳米粒子,在金纳米粒子表面连接硫辛酸改性的阿霉素(LA-DOX),从而间接实现了抗癌药物在PEGPAMAM内的高效负载.同时,LA-DOX中的酰腙键提供pH响应性,实现了药物的pH响应性释放.紫外-可见(UV-Vis)光谱表明,包覆金纳米粒子的PEG-PAMAM纳米载体对LA-DOX的负载能力显著增强.体外细胞实验表明,负载LA-DOX的树枝状聚合物-金纳米粒子复合药物载体具有较强的抗肿瘤能力.Dendrimer-gold nanoparticle composites were prepared based on poly(ethylene glycol) modified dendrimer(PEG-PAMAM). Gold nanoparticles internal provided an efficient platform for lipoic acid functionalized DoxorubicinLA-DOX linking,leading to the high loading efficiency of anticancer drugs DOX. Meanwhile the hydrazine linker in LA-DOX realized pH sensitive release for nanocarrier. Verified by UV-Vis spectra,the loading efficiency of LA-DOX in dendrimer-gold nanoparticle nanocomposite was improved. Cell Experiment indicated excellent cytotoxicity of dendrimer-gold nanoparticle composite against Hela cells.

关 键 词：树枝状聚合物 金纳米粒子 PH响应性 纳米药物 

分 类 号：O633[理学—高分子化学]