超声射频信号定量分析发现关节软骨退行性变的可行性研究  

Feasibility Study on Detection of Articular Cartilage Degeneration by Quantitative Analysis Based on Ultrasound Radio Frequency Signal

作　　者：李姗姗 王媛媛 孙洋[1] 何琼[2] 杨震[1] 罗建文[2] 崔立刚[1] LI Shanshan;WANG Yuanyuan;SUN Yang;HE Qiong;YANG Zhen;LUO Jianwen;CUI Ligang(Department of Ultrasound, Peking University Third Hospital, Beijing 100191, China;College of Biomedical Engineering,School of Medicine, Tsinghua University, Beijing 100084, China)

机构地区：[1]北京大学第三医院超声诊断科,北京100191 [2]清华大学医学院生物医学工程系,北京100084

出　　处：《中国医疗设备》2019年第5期11-14,共4页China Medical Devices

基　　金：国家重点研发计划(2016YFC0104902);北京市卫计委卫生科技成果和适宜技术推广(TG-2017-82)

摘　　要：目的探讨基于超声射频信号的多参数定量分析诊断股骨滑车软骨退行性变的可行性。方法选取行膝关节镜检查的患者58人60例膝关节,术前采集股骨滑车软骨的射频信号及高频超声灰阶图像,以关节镜为金标准判断滑车软骨是否退变并分为病例组和对照组。分别提取股骨滑车软骨区域10个参数进行统计学分析。同时利用常规高频超声灰阶图像进行诊断。结果其中,上边界粗糙度(URI_ant)、上边界反射强度、上边界反射均匀度及上边界和内部回波对比度在病例组与对照组间有统计学差异(P<0.01),其中应用ROC曲线以URI_ant为8.45为截断值判定软骨退变的AUC最大,灵敏性和特异性分别为72.5%和95.0%,常规高频超声的灵敏性和特异性分别为67.5%和80.0%。结论利用基于超声射频信号的多个参数定量评估股骨滑车软骨的退行性变具有可行性,且优于常规高频灰阶超声。Objective To investigate the feasibility of quantitative assessment based on ultrasound radio frequency(RF) signal in diagnosis of femoral trochlear cartilage degeneration in vivo. Methods A total of 58 patients, 60 cases of knee arthroscopy were enrolled in this study. Radio frequency signals and high-frequency ultrasound gray-scale images of trochlear cartilage were collected before the operations. Arthroscopy was used as the gold standard to determine whether the trochlear cartilage was degenerative, and the patients were divided into case group and control group. Ten parameters of the cartilage region of the trochlear femur were extracted for statistical analysis. Gray-scale ultrasound images were also collected for diagnosis. Results ultrasound roughness index of anterior surface(URI_ant), reflection coefficient of anterior surface, spatial variation of US reflection coefficient and contrast of reflection coefficient between anterior surface and interior cartilage were different between the case group and control group(P<0.01). The application of ROC curve for URI_ant 8.45 cutoff value to determine the largest AUC of cartilage degeneration, sensitivity and specificity were 72.5% and 95.0%, respectively. Conventional high frequency ultrasonic sensitivity and specificity of 67.5% and 80.0 %, respectively. Conclusion It is feasible to quantitatively evaluate the degeneration of femoral trochlear cartilage using multiple parameters based on ultrasonic radiofrequency signal, and it is better than conventional grayscale ultrasound.

关 键 词：超声射频信号 软骨 定量分析 退行性变 

分 类 号：R445.1[医药卫生—影像医学与核医学]