microRNAs与流感病毒感染  

MicroRNAs and Influenza Virus Infection

作　　者：张森 户义 李靖 康晓平 姜涛[1] ZHANG Sea;HU Yi;LI Jing;KANG Xiao-ping;JIANG Tao(Laboratory of Virology,State Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology,Beijing,100071,China)

机构地区：[1]军事科学院军事医学研究院微生物流行病研究所病原微生物与生物安全国家重点实验室病毒学专业实验室,北京100071

出　　处：《现代生物医学进展》2019年第5期965-968,共4页Progress in Modern Biomedicine

基　　金：国家重大传染病专项(2017ZX10305501-010);病原微生物生物安全重点实验室重点课题(SKLPBS1408)

摘　　要：MicroRNAs是一类数目庞大,而且可以广泛参与到生命活动各个进程的非编码RNA分子,在病毒感染宿主过程中存在着复杂的microRNAs与病毒的相互作用。流感病毒感染可以引起宿主microRNAs表达谱的明显变化,流感病毒能通过调控某些microRNAs的表达来实现免疫逃逸等增强其感染能力;同时,宿主也可以通过某些microRNAs的变化启动相应的抗流感病毒反应。本文主要针对流感病毒感染过程中宿主-病毒二者在microRNA水平的相互作用进行综述,以期更好的了解流感病毒的致病机制,为抗流感病毒的新药研制提供新的思路。MicroRNAs are a class of non-coding RNA molecules that are widely involved in various biological processes.There are complex interactions between host cellular microRNAs and viruses during viral infections.The expression of host cellular microRNAs is significantly altered in the influenza virus infection.The virus can utilize some microRNAs to achieve immune escape,while the host can also trigger a series of anti-influenza virus responses through changes in microRNAs expression.This article mainly reviews on the interaction between host and virus at the microRNAs level,in order to better understand the pathogenesis of the influenza virus and provide a new idea for the development of novel anti-influenza virus drugs.

关 键 词：流感病毒 MICRORNAS 宿主细胞 

分 类 号：Q52[生物学—生物化学] R34[医药卫生—基础医学]