氨甲酰促红细胞生成素的神经保护作用及机制的研究进展  

Research Progress on the Neuroprotective Effect and Mechanism of Carbamylated Erythropoietin

作　　者：席召燕 段淑荣[1] 陈明[1] 曹国娟 XI Zhao-yan;DUAN Shu-rong;CHEN Ming;CAO Guo-juan(The First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院神经内科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2019年第5期979-982,共4页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金重点项目(ZD201418)

摘　　要：氨甲酰促红细胞生成素(Carbamylated erythropoietin,CEPO)是促红细胞生成素(Erythropoietin,EPO)的一种衍生物,与EPO一样具有神经保护作用,但是没有其造血功能。已有大量实验研究证实了CEPO的神经保护作用,并有最新研究阐述了EPO和CEPO具有不同的信号转导通路。本文主要介绍了CEPO的减轻神经细胞水肿、促进神经细胞分化、改善神经功能恢复等神经保护作用及CEPO可能通过激活CEPO受体、CD131、神经胶质细胞源性的神经营养因子(Glial cell line derived neurotrophic factor,GDNF)、蛋白激酶B(Protein kinase B,Akt)等机制发挥其神经保护作用。CEPO,a derivative of EPO,has the same neuroproctive effect as EPO but no hematopoiesis.The neuroproction of CEPO has been confirmed by a number of experimental?studies and the different signal transduction pathways of EPO and CEPO is elaborated in latest study,indicate that CEPO is a promising neuroprotective agent and may be used in the clinic one day.This paper mainly introduced the neuroprotective effect of CEPO,including reducing edema,promoting differentiation,and improving function and discussed possible mechanisms including activing the receptor of CEPO and the CD131-GDNF-Akt pathway.

关 键 词：氨甲酰促红细胞生成素 神经保护 机制 促红细胞生成素 

分 类 号：R331[医药卫生—人体生理学] R338[医药卫生—基础医学]